Ongoing developments in cardiac modelling have resulted, in particular, in the development
of advanced and increasingly complex computational frameworks for simulating cardiac …

Controlling the complex spatio-temporal dynamics underlying life-threatening cardiac
arrhythmias such as fibrillation is extremely difficult, because of the nonlinear interaction of …

In the intact heart, the distribution of electromechanical delay (EMD), the time interval
between local depolarization and myocyte shortening onset, depends on the loading …

Cardiac defibrillation, as accomplished nowadays by automatic, implantable devices,
constitutes the most important means of combating sudden cardiac death. Advancing our …

Current understanding of cardiac electrophysiology has been greatly aided by
computational work performed using rabbit ventricular models. This article reviews the …

One of the most important contributions of biomedical engineering to medicine is the devel¬
opment of pacemakers, external defibrillators, and implantable cardioverters/defibrillators. 1 …

Several small shocks beat one big one | Nature Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Despite major successes of biophysical theories in predicting the effects of electrical shocks
within the heart, recent optical mapping studies have revealed two major discrepancies …

Twenty years of optical mapping of cardiac electrical activity and mathematical modeling of
the cardiac bidomain have provided insight into the basic mechanisms by which electric …

Detailed knowledge of tissue response to both systolic and diastolic shock is critical for
understanding defibrillation. Diastolic field stimulation has been much less studied than …