Hypoxia is prevalent in human tumours and contributes to microenvironments that shape
cancer evolution and adversely affect therapeutic outcomes. Historically, two different …

Diabetes mellitus has profound effects on multiple organ systems; however, the loss of
vision caused by diabetic retinopathy might be one of the most impactful in a patient's life …

The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …

Endothelial cells (ECs) are sentinels of cardiovascular health. Their function is reduced by
the presence of cardiovascular risk factors, and is regained once pathological stimuli are …

The vast blood-vessel network of the circulatory system is crucial for maintaining bodily
homeostasis, delivering essential molecules and blood cells, and removing waste products …

Endothelial barrier integrity is required for maintaining vascular homeostasis and fluid
balance between the circulation and surrounding tissues and for preventing the …

Tissue engineered vascular grafts (TEVGs) are beginning to achieve clinical success and
hold promise as a source of grafting material when donor grafts are unsuitable or …

Certain polymeric materials such as polyurethanes (PUs) are the most prevalent class of
used biomaterials in regenerative medicine and have been widely explored as vascular …

Liver fibrosis is a common feature of sustained liver injury and represents a major public
health problem worldwide. Fibrosis is an active research field and discoveries in the last …

It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …