Sepsis is an abnormal condition with multiple organ dysfunctions caused by the
uncontrolled infection response and one of the major diseases that seriously hang over …

The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

Rationale: Doxorubicin is one of the most potent antitumor agents available; however, its
clinical use is restricted because it poses a risk of severe cardiotoxicity. Previous work has …

Poor functional survival of the engrafted stem cells limits the therapeutic efficacy of stem-cell-
based therapy for myocardial infarction (MI). Cardiac patch-based system for cardiac repair …

Recent studies have shown that autophagy upregulation can attenuate sepsis-induced
acute kidney injury (SAKI). The tumor suppressor p53 has emerged as an autophagy …

Aims The apoptosis and autophagy play an important role in the pathogenesis of sepsis-
induced cardiac dysfunction. Previous studies have demonstrated that melatonin protects …

The mortality of sepsis-induced cardiac dysfunction (SICD) is very high due to the complex
pathophysiological mechanism. Syringaresinol (SYR) is a natural abstract which possesses …

Background Sepsis is a systemic inflammatory response that can lead to organ dysfunction
and/or circulatory disorders in severe cases. The dysregulated inflammatory response plays …

Sepsis is a serious complication after infection, whose further development may lead to
multiple organ dysfunction syndrome and so on. It is an important cause of death in critically …

Background Sepsis-associated encephalopathy (SAE) is characterized by diffuse brain
dysfunction, long-term cognitive impairment, and increased morbidity and mortality. The …