The rise of regulatory RNA

KV Morris, JS Mattick - Nature Reviews Genetics, 2014 - nature.com
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

Astrocyte glycogen and lactate: New insights into learning and memory mechanisms

CM Alberini, E Cruz, G Descalzi, B Bessières, V Gao - Glia, 2018 - Wiley Online Library
Memory, the ability to retain learned information, is necessary for survival. Thus far,
molecular and cellular investigations of memory formation and storage have mainly focused …

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing

G Barry, JA Briggs, DP Vanichkina, EM Poth… - Molecular …, 2014 - nature.com
Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning.
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …

[HTML][HTML] Understanding the physical basis of memory: Molecular mechanisms of the engram

C Ortega-de San Luis, TJ Ryan - Journal of Biological Chemistry, 2022 - ASBMB
Memory, defined as the storage and use of learned information in the brain, is necessary to
modulate behavior and critical for animals to adapt to their environments and survive …

Micro RNA‐125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease

J Banzhaf‐Strathmann, E Benito, S May… - The EMBO …, 2014 - embopress.org
Sporadic Alzheimer's disease (AD) is the most prevalent form of dementia, but no clear
disease‐initiating mechanism is known. Aβ deposits and neuronal tangles composed of …

Long‐term plasticity in the hippocampus: maintaining within and 'tagging'between synapses

MZ Bin Ibrahim, A Benoy, S Sajikumar - The FEBS journal, 2022 - Wiley Online Library
Synapses between neurons are malleable biochemical structures, strengthening and
diminishing over time dependent on the type of information they receive. This phenomenon …

How the epigenome integrates information and reshapes the synapse

RR Campbell, MA Wood - Nature Reviews Neuroscience, 2019 - nature.com
In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

[HTML][HTML] MicroRNAs shape the neuronal landscape

E McNeill, D Van Vactor - Neuron, 2012 - cell.com
The nervous system equips us with capability to adapt to many conditions and
circumstances. We rely on an armamentarium of intricately formed neural circuits for many of …

MicroRNAs in learning, memory, and neurological diseases

W Wang, EJ Kwon, LH Tsai - Learning & Memory, 2012 - learnmem.cshlp.org
MicroRNAs (miRNAs) represent a class of small regulatory noncoding RNAs∼ 22 bp in
length that mediate post-transcriptional silencing of gene expression via the recognition of …

[HTML][HTML] The gut-brain connection: Exploring the influence of the gut microbiota on neuroplasticity and neurodevelopmental disorders

F Damiani, S Cornuti, P Tognini - Neuropharmacology, 2023 - Elsevier
Neuroplasticity refers to the ability of brain circuits to reorganize and change the properties
of the network, resulting in alterations in brain function and behavior. It is traditionally …