The rise of regulatory RNA
KV Morris, JS Mattick - Nature Reviews Genetics, 2014 - nature.com
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …
suggests that RNA is not only functional as a messenger between DNA and protein but also …
Astrocyte glycogen and lactate: New insights into learning and memory mechanisms
CM Alberini, E Cruz, G Descalzi, B Bessières, V Gao - Glia, 2018 - Wiley Online Library
Memory, the ability to retain learned information, is necessary for survival. Thus far,
molecular and cellular investigations of memory formation and storage have mainly focused …
molecular and cellular investigations of memory formation and storage have mainly focused …
The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing
G Barry, JA Briggs, DP Vanichkina, EM Poth… - Molecular …, 2014 - nature.com
Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning.
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …
[HTML][HTML] Understanding the physical basis of memory: Molecular mechanisms of the engram
C Ortega-de San Luis, TJ Ryan - Journal of Biological Chemistry, 2022 - ASBMB
Memory, defined as the storage and use of learned information in the brain, is necessary to
modulate behavior and critical for animals to adapt to their environments and survive …
modulate behavior and critical for animals to adapt to their environments and survive …
Micro RNA‐125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease
J Banzhaf‐Strathmann, E Benito, S May… - The EMBO …, 2014 - embopress.org
Sporadic Alzheimer's disease (AD) is the most prevalent form of dementia, but no clear
disease‐initiating mechanism is known. Aβ deposits and neuronal tangles composed of …
disease‐initiating mechanism is known. Aβ deposits and neuronal tangles composed of …
Long‐term plasticity in the hippocampus: maintaining within and 'tagging'between synapses
Synapses between neurons are malleable biochemical structures, strengthening and
diminishing over time dependent on the type of information they receive. This phenomenon …
diminishing over time dependent on the type of information they receive. This phenomenon …
How the epigenome integrates information and reshapes the synapse
RR Campbell, MA Wood - Nature Reviews Neuroscience, 2019 - nature.com
In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …
encodes information to form long-lasting memories that lead to stable changes in behaviour …
[HTML][HTML] MicroRNAs shape the neuronal landscape
E McNeill, D Van Vactor - Neuron, 2012 - cell.com
The nervous system equips us with capability to adapt to many conditions and
circumstances. We rely on an armamentarium of intricately formed neural circuits for many of …
circumstances. We rely on an armamentarium of intricately formed neural circuits for many of …
MicroRNAs in learning, memory, and neurological diseases
MicroRNAs (miRNAs) represent a class of small regulatory noncoding RNAs∼ 22 bp in
length that mediate post-transcriptional silencing of gene expression via the recognition of …
length that mediate post-transcriptional silencing of gene expression via the recognition of …
[HTML][HTML] The gut-brain connection: Exploring the influence of the gut microbiota on neuroplasticity and neurodevelopmental disorders
Neuroplasticity refers to the ability of brain circuits to reorganize and change the properties
of the network, resulting in alterations in brain function and behavior. It is traditionally …
of the network, resulting in alterations in brain function and behavior. It is traditionally …