Role of liver sinusoidal endothelial cells in liver diseases

J Gracia-Sancho, E Caparrós… - Nature reviews …, 2021 - nature.com
Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Sinusoidal communication in liver fibrosis and regeneration

G Marrone, VH Shah, J Gracia-Sancho - Journal of hepatology, 2016 - Elsevier
Cellular crosstalk is a process through which a message is transmitted within an individual
cell (intracellular crosstalk) or between different cells (intercellular crosstalk). Intercellular …

Alternative splicing of CEACAM1 by hypoxia-inducible factor–1α enhances tolerance to hepatic ischemia in mice and humans

KJ Dery, H Kojima, S Kageyama, K Kadono… - Science translational …, 2023 - science.org
Although alternative splicing (AS) drives transcriptional responses and cellular adaptation to
environmental stresses, its contributions in organ transplantation have not been …

Cirrhosis as new indication for statins

J Bosch, J Gracia-Sancho, JG Abraldes - Gut, 2020 - gut.bmj.com
In the recent years, there have been an increasing number of reports on favourable effects of
statins in patients with advanced chronic liver disease. These include reduction in portal …

The emerging role of viability testing during liver machine perfusion

IMA Brüggenwirth, OB van Leeuwen… - Liver …, 2022 - Wiley Online Library
The transplant community continues to be challenged by the disparity between the need for
liver transplantation and the shortage of suitable donor organs. At the same time, the …

SP and KLF transcription factors in digestive physiology and diseases

CK Kim, P He, AB Bialkowska, VW Yang - Gastroenterology, 2017 - Elsevier
Specificity proteins (SPs) and Krüppel-like factors (KLFs) belong to the family of transcription
factors that contain conserved zinc finger domains involved in binding to target DNA …

[HTML][HTML] Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in …

X Tao, X Sun, L Xu, L Yin, X Han, Y Qi, Y Xu, Y Zhao… - Nutrients, 2016 - mdpi.com
The effects of total flavonoids (TFs) from Rosa laevigata Michx fruit against liver damage and
cerebral ischemia/reperfusion (I/R) injury have been reported, but its action on hepatic I/R …

[PDF][PDF] Emricasan ameliorates portal hypertension and liver fibrosis in cirrhotic rats through a hepatocyte‐mediated paracrine mechanism

J Gracia‐Sancho, N Manicardi… - Hepatology …, 2019 - Wiley Online Library
In cirrhosis, liver microvascular dysfunction is a key factor increasing hepatic vascular
resistance to portal blood flow, which leads to portal hypertension. De‐regulated …

[HTML][HTML] Automatic liver viability scoring with deep learning and hyperspectral imaging

E Felli, M Al-Taher, T Collins, R Nkusi, E Felli… - Diagnostics, 2021 - mdpi.com
Hyperspectral imaging (HSI) is a non-invasive imaging modality already applied to evaluate
hepatic oxygenation and to discriminate different models of hepatic ischemia. Nevertheless …

[HTML][HTML] Non-coding RNAs: The potential biomarker or therapeutic target in hepatic ischemia-reperfusion injury

JL Shao, LJ Wang, J Xiao, JF Yang - World Journal of …, 2023 - ncbi.nlm.nih.gov
Hepatic ischemia-reperfusion injury (HIRI) is the major complication of liver surgery and liver
transplantation, that may increase the postoperative morbidity, mortality, tumor progression …