Involvement of oxidative stress in the development of subcellular defects and heart disease

NS Dhalla, V Elimban, M Bartekova, A Adameova - Biomedicines, 2022 - mdpi.com
It is now well known that oxidative stress promotes lipid peroxidation, protein oxidation,
activation of proteases, fragmentation of DNA and alteration in gene expression for …

Monoamine oxidase‐related vascular oxidative stress in diseases associated with inflammatory burden

A Sturza, CM Popoiu, M Ionică… - Oxidative medicine …, 2019 - Wiley Online Library
Monoamine oxidases (MAO) with 2 isoforms, A and B, located at the outer mitochondrial
membrane are flavoenzyme membranes with a major role in the metabolism of …

Histamine can be Formed and Degraded in the Human and Mouse Heart

J Neumann, JM Grobe, J Weisgut… - Frontiers in …, 2021 - frontiersin.org
Histamine is metabolized by several enzymes in vitro and in vivo. The relevance of this
metabolism in the mammalian heart in vivo is unclear. However, histamine can exert positive …

Monoamine oxidases are novel sources of cardiovascular oxidative stress in experimental diabetes

A Sturza, OM Duicu, A Vaduva… - Canadian Journal of …, 2015 - cdnsciencepub.com
Diabetes mellitus (DM) is widely recognized as the most severe metabolic disease
associated with increased cardiovascular morbidity and mortality. The generation of reactive …

Assessment of mitochondrial dysfunction and monoamine oxidase contribution to oxidative stress in human diabetic hearts

OM Duicu, R Lighezan, A Sturza… - Oxidative medicine …, 2016 - Wiley Online Library
Mitochondria‐related oxidative stress is a pathomechanism causally linked to coronary heart
disease (CHD) and diabetes mellitus (DM). Recently, mitochondrial monoamine oxidases …

Increased MAO-A activity promotes progression of pulmonary arterial hypertension

XQ Sun, EL Peters, I Schalij, JB Axelsen… - American journal of …, 2021 - atsjournals.org
Monoamine oxidases (MAOs), a class of enzymes bound to the outer mitochondrial
membrane, are important sources of reactive oxygen species. Increased MAO-A activity in …

Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction

RG Goncharov, MG Sharapov - Molecular Biology, 2023 - Springer
Ischemia–reperfusion is a cascade of complex and interrelated pathological processes
underlying many human diseases, including such socially significant diseases as stroke …

Effects of berberine on cholinesterases and monoamine oxidase activities, and antioxidant status in the brain of streptozotocin (STZ)-induced diabetic rats

SA Adefegha, FA Dada, SI Oyeleye… - Journal of Basic and …, 2022 - degruyter.com
Objectives Several studies had been conducted to examine the link between diabetes and
diabetes encephalopathy. This study was conducted to examine the potency of berberine …

Monoamine oxidase inhibition improves vascular function in mammary arteries from nondiabetic and diabetic patients with coronary heart disease

R Lighezan, A Sturza, OM Duicu… - Canadian journal of …, 2016 - cdnsciencepub.com
Monoamine oxidases (MAOs) are mitochondrial enzymes with 2 isoforms that have emerged
as important contributors to cardiovascular oxidative stress via the constant generation of …

Methylene blue improves mitochondrial respiration and decreases oxidative stress in a substrate-dependent manner in diabetic rat hearts

OM Duicu, A Privistirescu, A Wolf… - Canadian Journal of …, 2017 - cdnsciencepub.com
Diabetic cardiomyopathy has been systematically associated with compromised
mitochondrial energetics and increased generation of reactive oxygen species (ROS) that …