Purpose Recent years have seen a change in the way that clinical trials are being
conducted. There has been a rise of designs more flexible than traditional adaptive and …

Importance Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019
(COVID-19) is associated with substantial mortality and use of health care resources …

Corticosteroids, such as hydrocortisone and dexamethasone, haveanti-inflammatory,
antifibrotic, andvasoconstrictiveeffects, which intensivists have been trying to leverage for …

Background Angiotensin-converting enzyme-2 (ACE2) expression may increase due to
upregulation in patients using angiotensin-converting enzyme inhibitors (ACEI) and …

Summary Background Previous Randomised controlled trials (RCT) evaluating chloroquine
and hydroxychloroquine in non-hospitalised COVID-19 patients have found no significant …

Objective: The infection caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) spreads worldwide and is considered a pandemic. The most common …

Background Revision total knee arthroplasty (rTKA) is associated with significant risk of
wound-related morbidity. The present study aimed to evaluate the 1) efficacy of closed …

Introduction Intracytoplasmic sperm injection (ICSI), originally introduced as add-on to in
vitro fertilisation (IVF) for couples with severe male infertility, is in current clinical practice …

Background: Experimental treatments pass through various stages of development. If a
treatment passes through early-phase experiments, the investigators may want to assess it …

Introduction Presently, there are few population-level strategies to address SARS-CoV-2
infection except preventive measures such as vaccination. Micronutrient deficiency …