Current pharmacotherapy and multi-target approaches for Alzheimer's disease
SL Cheong, JK Tiew, YH Fong, HW Leong, YM Chan… - Pharmaceuticals, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
An ongoing journey of chalcone analogues as single and multi-target ligands in the field of Alzheimer's disease: A review with structural aspects
Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disorder with
progressive dementia and cognitive impairment. AD poses severe health challenge in …
progressive dementia and cognitive impairment. AD poses severe health challenge in …
Discovery of chalcone derivatives as potential α-glucosidase and cholinesterase inhibitors: Effect of hyperglycemia in paving a path to dementia
In the present study, a series of fascinating chalcone derivatives 1C-14C has been designed
and synthesized by Claisen-Schmidt condensation. The target compounds were screened …
and synthesized by Claisen-Schmidt condensation. The target compounds were screened …
Piperazine-substituted chalcones: A new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders
Abstract Eleven piperazine-containing 1, 3-diphenylprop-2-en-1-one derivatives (PC1-
PC11) were evaluated for their inhibitory activities against monoamine oxidases (MAOs) …
PC11) were evaluated for their inhibitory activities against monoamine oxidases (MAOs) …
Trimethoxylated halogenated chalcones as dual inhibitors of MAO-B and BACE-1 for the treatment of neurodegenerative disorders
VP Koyiparambath, JM Oh, A Khames… - Pharmaceutics, 2021 - mdpi.com
Six halogenated trimethoxy chalcone derivatives (CH1–CH6) were synthesized and
spectrally characterized. The compounds were further evaluated for their inhibitory potential …
spectrally characterized. The compounds were further evaluated for their inhibitory potential …
Dual-Target Inhibitors Based on Acetylcholinesterase: Novel Agents for Alzheimer's Disease
X Zhao, Q Hu, X Wang, C Li, X Chen, D Zhao… - European Journal of …, 2024 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia among the elderly,
accounting for 60% to 70% of cases. At present, the pathogenesis of this condition remains …
accounting for 60% to 70% of cases. At present, the pathogenesis of this condition remains …
Latest advances in dual inhibitors of acetylcholinesterase and monoamine oxidase B against Alzheimer's disease
D Zou, R Liu, Y Lv, J Guo, C Zhang… - Journal of Enzyme …, 2023 - Taylor & Francis
Alzheimer's disease (AD) is a progressive brain disease characterised by progressive
memory loss and cognition impairment, ultimately leading to death. There are three FDA …
memory loss and cognition impairment, ultimately leading to death. There are three FDA …
Identification of New N-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors
AK El-Damasy, JE Park, HJ Kim, J Lee, EK Bang… - Pharmaceuticals, 2023 - mdpi.com
Monoamine oxidase-B (MAO-B), acetylcholinesterase (AChE), and butyrylcholinesterase
(BChE) have been considered target enzymes of depression and neurodegenerative …
(BChE) have been considered target enzymes of depression and neurodegenerative …
Chalcones as potential ligands for the treatment of Parkinson's disease
E Królicka, K Kieć-Kononowicz, D Łażewska - Pharmaceuticals, 2022 - mdpi.com
Along with the increase in life expectancy, a significant increase of people suffering from
neurodegenerative diseases (ND) has been noticed. The second most common ND, after …
neurodegenerative diseases (ND) has been noticed. The second most common ND, after …
Benzimidazole-derived carbohydrazones as dual monoamine oxidases and acetylcholinesterase inhibitors: design, synthesis, and evaluation
A series of novel benzimidazole-derived carbohydrazones was designed, synthesized and
evaluated for their dual inhibition potential against monoamine oxidases (MAOs) and …
evaluated for their dual inhibition potential against monoamine oxidases (MAOs) and …