Ground-based rodent models have established that space radiation doses (approximately
those that astronauts will be exposed to on a mission to Mars) significantly impair …

Food intake follows a predictable daily pattern and synchronizes metabolic rhythms.
Neurons expressing agouti-related protein (AgRP) read out physiological energetic state …

Under natural conditions, many aspects of the abiotic and biotic environment vary with time
of day, season or even era, while these conditions are typically kept constant in laboratory …

Peripheral circadian clocks in mammals are strongly entrained by light-dark and eating
cycles. Their physiological functions are maintained by the synchronization of the phase of …

Calorie restriction (CR) increases longevity in many species by unknown mechanisms. The
circadian clock was proposed as a potential mediator of CR. Deficiency of the core …

Daily rhythms of food anticipatory activity (FAA) are regulated independently of the
suprachiasmatic nucleus, which mediates entrainment of rhythms to light, but the neural …

For many animal species, knowing when to look for food may be as important as knowing
where to look. Rats and other species use a feeding-responsive circadian timing mechanism …

Male C57BL/6 mice fed ad libitum on control diet but allowed access to a palatable high fat
diet (HFD) for 2 ha day during the mid-dark phase rapidly adapt their feeding behaviour and …

Anorexia nervosa is one of the most debilitating mental illnesses that emerges during
adolescence, especially among females. Anorexia nervosa is characterized by severe …

Calorie restriction (CR) delays the onset of age-related disease and extends lifespan in a
number of species. When faced with reduced energy supply animals need to lower energy …