The family of G protein‐coupled receptors (GPCRs) constitutes the largest class of signalling
receptors in the human genome, controlling vast physiological responses and are the target …

Review of the available evidence for physiological and pathophysiological roles of the
serine protease plasmin in inflammatory processes. The serine protease plasmin generated …

Proteinase-activated receptors (PARs) are a subfamily of G protein-coupled receptors
(GPCRs) with four members, PAR 1, PAR 2, PAR 3 and PAR 4, playing critical functions in …

Hyperfibrinolysis is a systemic condition occurring in various clinical disorders such as
trauma, liver cirrhosis, and leukemia. Apart from increased bleeding tendency, the …

Sphingolipids are a fascinating class of signaling molecules derived from the membrane
lipid sphingomyelin. They show abundant expression in the brain. Complex sphingolipids …

Plasmin, the principal downstream product of tissue-type plasminogen activator (tPA), is
known for its potent fibrin-degrading capacity but is also recognized for many non-fibrinolytic …

Thrombin is a Na+-activated allosteric serine protease of the chymotrypsin family involved in
coagulation, inflammation, cell protection, and apoptosis. Increasingly, the role of thrombin …

Abstract Mutations in SRPX2 (Sushi-Repeat Protein, X-linked 2) cause rolandic epilepsy
with speech impairment (RESDX syndrome) or with altered development of the speech …

Serine proteases, serine protease inhibitors, and protease-activated receptors have been
intensively investigated in the periphery and their roles in a wide range of processes …

Thrombin, a serine protease involved in the blood coagulation cascade has been shown to
affect neural function following blood-brain barrier breakdown. However, several lines of …