Normal maintenance of human motivation depends on the integrity of subcortical structures
that link the prefrontal cortex with the limbic system. Structural and functional disruption of …

Deep brain stimulation (DBS) of 3 different targets is the most important therapeutic
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …

The objective was to update previous evidence‐based medicine reviews of treatments for
motor symptoms of Parkinson's disease published between 2002 and 2005. Level I …

Introduction: Deep brain stimulation is a safe and effective neurointerventional technique for
the treatment of movement disorders. Electrical stimulation of subcortical structures may …

Deep-brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment
for motor complications in Parkinson's disease. 20 years of experience with this procedure …

Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces motor
symptoms in patients with Parkinson's disease (PD) and improves their quality of life; …

Apathy has been reported to occur after subthalamic nucleus stimulation, a treatment of
motor complications in advanced Parkinson's disease. We carried out a prospective study of …

Addictions to dopaminergic drugs or to pleasant behaviours are frequent and potentially
devastating neuropsychiatric disorders observed in Parkinson's disease. They encompass …

Although Parkinson's disease (PD) is primarily considered a disorder of initiation of actions,
patients also have deficits in inhibitory control, both in the motor and cognitive domains …

Only a few years after the introduction of levodopa, the first descriptions of motor fluctuations
and dyskinesia related to dopaminergic therapy appeared. In PD, attention turned to their …