After several decades of intensive efforts, safe injectable preparations capable of effectively
delivering O2 to tissues and removing CO2, ie, so-called blood substitutes, appear to be …

Red cells are the oxygen-carrying components of blood. In modern medical practice,
transfusions are given as suspensions of type-matched red cells in saline to replace lost …

A versatile and environmentally friendly synthetic method for the formation of acyl
phosphates is reported. By employing electrochemical oxidative dehydrogenative coupling …

Nucleoside monophosphates, when activated by trifluoroacetic anhydride and N-
methylimidazole, efficiently couple with a variety of electron-deficient diphosphonates in a …

Hemoglobin-based oxygen carriers have been sought as stable, sterile alternatives to red
cells in transfusions. Problems in clinical trials using cross-linked tetramers have led to …

Chemical cross-linking of human adult hemoglobin (Hb) prevents dissociation of the
tetrameric (αβ) 2 protein into its constituent non-functional αβ dimers when present outside …

A copper-catalyzed oxidative dehydrogenative coupling of carboxylic acids with H-
phosphonates is developed. This transformation exhibits a wide substrate scope and good …

Acyl phosphate monoesters are intermediates in many biochemical acylation reactions,
such as those involving aminoacyl adenylates. Benzoyl methyl phosphate, a typical acyl …

Hemoglobin has been a long-standing paradigm for understanding protein allostery. Here,
the x-ray structures of two chemically crosslinked, fully liganded hemoglobins, α2β82CA82β …

The direct monoacylation of diols by acyl phosphate monoesters in water is a biomimetic
analogy to the enzymic aminoacylation of tRNA by aminoacyl adenylates. Without catalysis …