Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

The lysosome degrades and recycles macromolecules, signals to the cytosol and nucleus,
and is implicated in many diseases. Here, we describe a method for the rapid isolation of …

In my PNAS Inaugural Article, I describe the development of the mTOR field, starting with
efforts to understand the mechanism of action of the drug rapamycin, which∼ 25 y ago led to …

Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …

Leucine is a proteogenic amino acid that also regulates many aspects of mammalian
physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a …

The mechanistic target of rapamycin (mTOR) has gathered significant attention as a
ubiquitously expressed multimeric kinase with key implications for cell growth, proliferation …

Amino acids signal to the mTOR complex I (mTORC1) growth pathway through the Rag
GTPases. Multiple distinct complexes regulate the Rags, including GATOR1, a GTPase …