The skeletal muscle is the largest organ in the body, by mass. It is also the regulator of
glucose homeostasis, responsible for 80% of postprandial glucose uptake from the …

Programmed cell death, or apoptosis, is a complex process whereby eukaryotic cells react to
physiologic or pathophysiologic stimuli by undergoing genetically programmed suicide …

Major depression is a highly prevalent severe mood disorder that is treated with
antidepressants. The molecular targets of antidepressants require definition. We …

A novel pH-sensitive drug delivery system of mesoporous silica nanoparticles (MSNs) which
were modified by polydopamine (PDA) for controlled release of cationic amphiphilic drug …

Abstract Aims: Pulmonary infections with Pseudomonas aeruginosa are a serious clinical
problem and are often lethal. Because many strains of P. aeruginosa are resistant to …

Acid sphingomyelinase (ASM), a key enzyme in sphingolipid metabolism, hydrolyzes
sphingomyelin to ceramide and phosphorylcholine. In mammals, the expression of a single …

Microvesicles (MVs) are released from almost all cell brain types into the microenvironment
and are emerging as a novel way of cell-to-cell communication. This review focuses on MVs …

Amitriptyline, a tricyclic antidepressant, has been used in the clinic to treat a number of
disorders, in particular major depression and neuropathic pain. In the 1970s the ability of …

Tumor microenvironment is fundamental for cancer progression and chemoresistance.
Among stromal cells tumor-associated macrophages (TAMs) represent the largest …

The endocrine system participates in regulating macrophage maturation, although little is
known about the modulating role of the thyroid hormones. In vitro results demonstrate a …