The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Cellular therapies are poised to transform the field of medicine by restoring dysfunctional
tissues and treating various diseases in a dynamic manner not achievable by conventional …

Refractoriness to platelet transfusion is a major problem in a small group of patients, and
large-scale manufacturing of clinical grade functional platelets ex vivo has remained an …

Human induced pluripotent stem cells (iPSCs) can be limitlessly expanded and
differentiated into almost all cell types. Moreover, they are amenable to gene manipulation …

Despite significant advancements in the production of platelet products, storage, and
transfusion, transfusion refractoriness remains a significant clinical problem, affecting up to …

The ex vivo production of platelets depleted of human leukocyte antigen class I (HLA-I)
could serve as a universal measure to overcome platelet transfusion refractoriness caused …

Immune rejection remains the major obstacle to long-term survival of allogeneic lung
transplants. The expression of major histocompatibility complex molecules and minor …

Platelet derived bio-products in the form of platelet rich plasma, plasma rich in growth
factors, or plasma-free platelet releasates, are being studied worldwide with the aim of …

The implementation of induced pluripotent stem cells (iPSCs) in biomedical research more
than a decade ago, resulted in a huge leap forward in the highly promising area of …

Organ gene therapy represents a promising tool to correct diseases or improve graft survival
after transplantation. Polymorphic variation of the major histocompatibility complex (MHC) …