Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Targeting of PARP enzymes has emerged as an effective therapeutic strategy to selectively
target cancer cells with deficiencies in homologous recombination signaling. Currently used …

Imaging reveals complex structures and dynamic interactive processes, located deep inside
the body, that are otherwise difficult to decipher. Numerous imaging modalities harness …

Owing to improvements in our understanding of the biological principles of tumour initiation
and progression, a wide variety of novel targeted therapies have been developed …

Pharmacokinetic analysis at the organ level provides insight into how drugs distribute
throughout the body, but cannot explain how drugs work at the cellular level. Here we …

Molecular imaging is a biomedical research discipline that has quickly emerged to afford the
observation, characterization, monitoring, and quantification of biomarkers and biological …

Poly (ADP-ribose) polymerase-1 (PARP1) is a DNA repair enzyme highly expressed in the
nuclei of mammalian cells, with a structure and function that have attracted interest since its …

Purpose: Glioblastoma multiforme is a highly aggressive form of brain cancer whose
location, tendency to infiltrate healthy surrounding tissue, and heterogeneity significantly …

Purpose Imaging the PARP expression using 18F probes has been approved in clinical
trials. Nevertheless, hepatobiliary clearance of both 18F probes hindered their application in …

Poly (ADP-ribose) polymerase (PARP) inhibitors are increasingly being studied as cancer
drugs, as single agents, or as a part of combination therapies. Imaging of PARP using a …