Noble metals in medicine: Latest advances

S Medici, M Peana, VM Nurchi, JI Lachowicz… - Coordination Chemistry …, 2015 - Elsevier
History shows that metal-based drugs and remedies have been known and used since very
ancient times. For example, silver was employed in the treatment of wounds and ulcers …

Update on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugs

W Liu, R Gust - Coordination Chemistry Reviews, 2016 - Elsevier
The clinical success of platinum-based chemotherapeutic agents was of enormous impact
on the discovery of novel metal N-heterocyclic carbene (NHC) complexes as potential anti …

Gold-based medicine: a paradigm shift in anti-cancer therapy?

CI Yeo, KK Ooi, ERT Tiekink - Molecules, 2018 - mdpi.com
A new era of metal-based drugs started in the 1960s, heralded by the discovery of potent
platinum-based complexes, commencing with cisplatin [(H3N) 2PtCl2], which are effective …

Cellular transport mechanisms of cytotoxic metallodrugs: An overview beyond cisplatin

S Spreckelmeyer, C Orvig, A Casini - Molecules, 2014 - mdpi.com
The field of medicinal inorganic chemistry has grown consistently during the past 50 years;
however, metal-containing coordination compounds represent only a minor proportion of …

Gold (I) NHC-based homo-and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents

B Bertrand, A Citta, IL Franken, M Picquet… - JBIC Journal of …, 2015 - Springer
While N-heterocyclic carbenes (NHC) are ubiquitous ligands in catalysis for organic or
industrial syntheses, their potential to form transition metal complexes for medicinal …

Coordination chemistry of 1, 3, 5-triaza-7-phosphatricyclo [3.3. 1.1] decane (PTA) and derivatives. Part III. Variations on a theme: Novel architectures, materials and …

A Guerriero, M Peruzzini, L Gonsalvi - Coordination Chemistry Reviews, 2018 - Elsevier
This review paper covers the recent (2010–2017) synthetic modifications of the water
soluble cage-like aminophosphine ligand 1, 3, 5-triaza-7-phosphatricyclo [3.3. 1.1] decane …

Cytotoxicity and biodistribution studies of luminescent Au (I) and Ag (I) N-heterocyclic carbenes. Searching for new biological targets

R Visbal, V Fernández-Moreira, I Marzo… - Dalton …, 2016 - pubs.rsc.org
A range of fluorescent and biologically compatible gold (I)–N-heterocyclic carbenes bearing
acridine as a wingtip group and either a 2-mercaptopyridine or a tetra-O-acetyl-1-thio-β-D …

New luminescent polynuclear metal complexes with anticancer properties: toward structure–activity relationships

M Wenzel, A De Almeida, E Bigaeva… - Inorganic …, 2016 - ACS Publications
A series of new heterodinuclear luminescent complexes with two different organic ligands
have been synthesized and characterized. A luminescent RuII (polypyridine) moiety and a …

Cytotoxic Gold (I) N‐heterocyclic Carbene Complexes with Phosphane Ligands as Potent Enzyme Inhibitors

R Rubbiani, L Salassa, A De Almeida… - …, 2014 - Wiley Online Library
Organometallic gold complexes with N‐heterocyclic carbene (NHC) ligands have been
demonstrating promising properties as novel anticancer agents. Gold (I) NHC complexes …

Exploring the potential of gold (III) cyclometallated compounds as cytotoxic agents: variations on the C^ N theme

B Bertrand, S Spreckelmeyer, E Bodio, F Cocco… - Dalton …, 2015 - pubs.rsc.org
A series of novel (C^ N) cyclometallated Au (III) complexes of general formula [Au (pyb-H)
L1L2] n+ (pyb-H= C^ N cyclometallated 2-benzylpyridine, L1 and L2 being chlorido …