Extracellular vesicles (EV) consist of exosomes, which are released upon fusion of the
multivesicular body with the cell membrane, and microvesicles, which are released directly …

The immunosuppressive potential of mesenchymal stem cells has been extensively
investigated in many studies in vivo and in vitro. In recent years, a variety preclinical and …

To date, cellular transplantation therapy has not yet fulfilled its high expectations for cardiac
repair. A major limiting factor is lack of long‐term engraftment of the transplanted cells …

The observations that mesenchymal stem cells (MSCs) exert cardiac protection and repair
via their secretome with the active component (s) identified as exosomes underpinned our …

Cell transplantation studies have shown that injection of progenitor cells can improve
cardiac function after myocardial infarction (MI). Transplantation of human cardiac progenitor …

Biomaterials to be used as cell delivery systems for cardiac tissue engineering should be
able to comply with cardiac muscle contractile activity, while favoring cell survival and neo …

Although cell survival post-transplantation is very low, emerging evidence using stem cell
therapy for myocardial repair points toward a primary role of paracrine signaling …

The microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the
heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key …

Stem cell transplantation therapy is a promising adjunct for regenerating damaged heart
tissue; however, only modest improvements in cardiac function have been observed due to …

A variety of paracrine signals create networks within the myocardium and mediate
intercellular communications. Indeed, paracrine stimulation of the endogenous regenerative …