Solar ultraviolet (UV) radiation generates bulky photodimers at di-pyrimidine sites that pose
stress to cells and organisms by hindering DNA replication and transcription. In addition …

The encounter of elongating RNA polymerase II (RNAPIIo) with DNA lesions has severe
consequences for the cell as this event provides a strong signal for P53-dependent …

DNA–protein crosslinks (DPCs) are large cytotoxic DNA lesions that form following exposure
to chemotherapeutic drugs and environmental chemicals. Nucleotide excision repair (NER) …

Induction of apoptosis of keratinocytes by ultraviolet (UV) radiation is a protective
phenomenon relevant in limiting the survival of cells with irreparable DNA damage …

DNA damage, provoked by ultraviolet (UV) radiation, evokes a cellular damage response
composed of activation of stress signaling and DNA checkpoint functions. These are …

Cells induce the expression of DNA-repair enzymes, activate cell-cycle checkpoints and,
under some circumstances, undergo apoptosis in response to DNA-damaging agents. The …

A network of DNA damage surveillance systems is triggered by sensing of DNA lesions and
the initiation of a signal transduction cascade that activates genome-protection pathways …

UVB radiation is the most mutagenic component of the UV spectrum that reaches the earth's
surface and causes the development of DNA damage in the form of cyclobutane pyrimidine …

The immunostimulatory cytokine IL-12 is able to antagonize immunosuppression induced by
solar/ultraviolet (UV) radiation via yet unknown mechanisms. IL-12 was recently found to …

Induction of DNA damage by solar UV radiation is a key event in the development of skin
cancers. Bipyrimidine photoproducts, including cyclobutane pyrimidine dimers (CPDs),(6-4) …