Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …

In this paper, we present a literature review of the role of CXC motif chemokine ligand 1
(CXCL1) in physiology, and in selected major non-cancer diseases of the cardiovascular …

Although elevated cholesterol and other recognised cardiovascular risk factors are important
in the development of coronary artery disease (CAD) and heart attack, the susceptibility of …

Liver dysfunction in sepsis is a major complication that amplifies multiple organ failure and
increases the risk of death. Inflammation and oxidative stress are the main mediators in the …

Sepsis-associated acute liver injury (ALI) is a deadly condition resulting from a systemic
inflammatory response to liver cell damage and malfunction. Monotropein (MON) belongs to …

Aims Homocysteine has been linked to neurodegeneration and motor function impairments.
In the present study, we evaluate the effect of chronic mild hyperhomocysteinemia on the …

P2X receptors (P2XRs) are trimeric, non-selective cation channels activated by extracellular
ATP and widely distributed in the digestive system. P2XRs have an important role in the …

Toxoplasmosis is a globally significant disease that poses a severe threat to
immunocompromised individuals, especially in Brazil, where a high prevalence of virulent …

Sepsis is a deadly systemic inflammatory response of the body against infection resulting in
immune response, cell differentiation and organ damage. Endotoxemia is one of the causes …

Chagas disease (CD) is caused by the parasite Trypanosoma cruzi. CD affects people
worldwide, primarily in tropical areas. The central nervous system (CNS) is an essential site …