Spermidine in health and disease
BACKGROUND As the world population ages, chronic diseases such as diabetes,
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …
Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases
MD Lovelace, B Varney, G Sundaram, MJ Lennon… - …, 2017 - Elsevier
The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a
key regulator of the production of both neuroprotective (eg kynurenic and picolinic acid, and …
key regulator of the production of both neuroprotective (eg kynurenic and picolinic acid, and …
[HTML][HTML] Antiaging agents: Safe interventions to slow aging and healthy life span extension
JK Liu - Natural Products and Bioprospecting, 2022 - Springer
Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …
billion population of the world will exceed the age of 60 in 2050. Since the last three …
L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences
H Fujigaki, Y Yamamoto, K Saito - Neuropharmacology, 2017 - Elsevier
The kynurenine pathway (KP) is the major route for tryptophan (TRP) metabolism in most
mammalian tissues. The KP metabolizes TRP into a number of neuroactive metabolites …
mammalian tissues. The KP metabolizes TRP into a number of neuroactive metabolites …
[HTML][HTML] A six-metabolite panel as potential blood-based biomarkers for Parkinson's disease
Characterisation and diagnosis of idiopathic Parkinson's disease (iPD) is a current
challenge that hampers both clinical assessment and clinical trial development with the …
challenge that hampers both clinical assessment and clinical trial development with the …
Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation
AM Garrison, JM Parrott, A Tuñon, J Delgado… - …, 2018 - Elsevier
Chronic stress or inflammation increases tryptophan metabolism along the kynurenine
pathway (KP), and the generation of neuroactive kynurenine metabolites contributes to …
pathway (KP), and the generation of neuroactive kynurenine metabolites contributes to …
[HTML][HTML] Neuroprotective effect of α-mangostin in ameliorating propionic acid-induced experimental model of autism in Wistar rats
Several studies have documented the role of hyper-activation of extracellular signal-
regulated kinases (ERK) in Autism pathogenesis. Alpha-mangostin (AMG) is a …
regulated kinases (ERK) in Autism pathogenesis. Alpha-mangostin (AMG) is a …
Spermidine, an autophagy inducer, as a therapeutic strategy in neurological disorders
Spermidine is a naturally occurring endogenous polyamine synthesized from diamine
putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal …
putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal …
Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and …
Multiple Sclerosis (MS) is a progressive neurodegenerative disease with clinical signs of
neuroinflammation and the central nervous system's demyelination. Numerous studies have …
neuroinflammation and the central nervous system's demyelination. Numerous studies have …
[HTML][HTML] A mitochondria-associated oxidative stress perspective on Huntington's disease
J Zheng, J Winderickx, V Franssens… - Frontiers in molecular …, 2018 - frontiersin.org
Huntington's disease (HD) is genetically caused by mutation of the Huntingtin (HTT) gene. At
present, the mechanisms underlying the defect of HTT and the development of HD remain …
present, the mechanisms underlying the defect of HTT and the development of HD remain …