Engineering the IL‐4/IL‐13 axis for targeted immune modulation

ZJ Bernstein, A Shenoy, A Chen… - Immunological …, 2023 - Wiley Online Library
The structurally and functionally related interleukin‐4 (IL‐4) and IL‐13 cytokines play pivotal
roles in shaping immune activity. The IL‐4/IL‐13 axis is best known for its critical role in T …

Astrocytic Chitinase‐3‐like protein 1 in neurological diseases: Potential roles and future perspectives

F Li, A Liu, M Zhao, L Luo - Journal of Neurochemistry, 2023 - Wiley Online Library
Abstract Chitinase‐3‐like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its
ability to regulate multiple biological processes, such as the inflammatory response and …

Supervised discovery of interpretable gene programs from single-cell data

RZ Kunes, T Walle, M Land, T Nawy, D Pe'er - Nature Biotechnology, 2024 - nature.com
Factor analysis decomposes single-cell gene expression data into a minimal set of gene
programs that correspond to processes executed by cells in a sample. However, matrix …

Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer

JE Yu, IJ Yeo, SB Han, J Yun, B Kim, YJ Yong… - … & Molecular Medicine, 2024 - nature.com
Abstract Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates
inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of …

A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1

L Hai, DC Hoffmann, RJ Wagener, DD Azorin… - Nature …, 2024 - nature.com
Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for
tumor progression and therapy resistance. However, the determination of TM …

Potential Roles and Future Perspectives of Chitinase 3-like 1 in Macrophage Polarization and the Development of Diseases

H Zhao, M Huang, L Jiang - International Journal of Molecular Sciences, 2023 - mdpi.com
Chitinase-3-like protein 1 (CHI3L1), a chitinase-like protein family member, is a secreted
glycoprotein that mediates macrophage polarization, inflammation, apoptosis, angiogenesis …

The Role of Chitinase-3-like Protein-1 (YKL40) in the Therapy of Cancer and Other Chronic-Inflammation-Related Diseases

MC Chang, CT Chen, PF Chiang, YC Chiang - Pharmaceuticals, 2024 - mdpi.com
Chitinase-3-like protein-1 (CHI3L1), also known as YKL40, is a glycoprotein that belongs to
the chitinase protein family. It is involved in various biological functions, including cell …

Roles of IL-4, IL-13, and Their Receptors in Lung Cancer

Y Zhang, K Zhu, X Wang, Y Zhao, J Shi… - Journal of Interferon & …, 2024 - liebertpub.com
Interleukin (IL)-4 and IL-13 are the main effectors of innate lymphoid cells (ILC2) of the type
2 innate immune response, which can carry out specific signal transmission between …

Small Molecule Immunomodulators as Next-Generation Therapeutics for Glioblastoma

SA Abdel-Rahman, M Gabr - Cancers, 2024 - mdpi.com
Simple Summary Glioblastoma (GBM) is an aggressive brain tumor with limited treatment
success. Despite efforts, the prognosis remains poor, impacting patients' quality of life …

CHI3L1 induces autophagy through the JNK pathway in lung cancer cells

DE Hong, JE Yu, SS Yoo, IJ Yeo, DJ Son, J Yun… - Scientific Reports, 2023 - nature.com
CHI3L1 is closely related to the molecular mechanisms of cancer cell migration, growth, and
death. According to recent research, autophagy regulates tumor growth during various …