Engineering the IL‐4/IL‐13 axis for targeted immune modulation
ZJ Bernstein, A Shenoy, A Chen… - Immunological …, 2023 - Wiley Online Library
The structurally and functionally related interleukin‐4 (IL‐4) and IL‐13 cytokines play pivotal
roles in shaping immune activity. The IL‐4/IL‐13 axis is best known for its critical role in T …
roles in shaping immune activity. The IL‐4/IL‐13 axis is best known for its critical role in T …
Astrocytic Chitinase‐3‐like protein 1 in neurological diseases: Potential roles and future perspectives
F Li, A Liu, M Zhao, L Luo - Journal of Neurochemistry, 2023 - Wiley Online Library
Abstract Chitinase‐3‐like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its
ability to regulate multiple biological processes, such as the inflammatory response and …
ability to regulate multiple biological processes, such as the inflammatory response and …
Supervised discovery of interpretable gene programs from single-cell data
Factor analysis decomposes single-cell gene expression data into a minimal set of gene
programs that correspond to processes executed by cells in a sample. However, matrix …
programs that correspond to processes executed by cells in a sample. However, matrix …
Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer
Abstract Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates
inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of …
inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of …
A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
L Hai, DC Hoffmann, RJ Wagener, DD Azorin… - Nature …, 2024 - nature.com
Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for
tumor progression and therapy resistance. However, the determination of TM …
tumor progression and therapy resistance. However, the determination of TM …
Potential Roles and Future Perspectives of Chitinase 3-like 1 in Macrophage Polarization and the Development of Diseases
Chitinase-3-like protein 1 (CHI3L1), a chitinase-like protein family member, is a secreted
glycoprotein that mediates macrophage polarization, inflammation, apoptosis, angiogenesis …
glycoprotein that mediates macrophage polarization, inflammation, apoptosis, angiogenesis …
The Role of Chitinase-3-like Protein-1 (YKL40) in the Therapy of Cancer and Other Chronic-Inflammation-Related Diseases
MC Chang, CT Chen, PF Chiang, YC Chiang - Pharmaceuticals, 2024 - mdpi.com
Chitinase-3-like protein-1 (CHI3L1), also known as YKL40, is a glycoprotein that belongs to
the chitinase protein family. It is involved in various biological functions, including cell …
the chitinase protein family. It is involved in various biological functions, including cell …
Roles of IL-4, IL-13, and Their Receptors in Lung Cancer
Y Zhang, K Zhu, X Wang, Y Zhao, J Shi… - Journal of Interferon & …, 2024 - liebertpub.com
Interleukin (IL)-4 and IL-13 are the main effectors of innate lymphoid cells (ILC2) of the type
2 innate immune response, which can carry out specific signal transmission between …
2 innate immune response, which can carry out specific signal transmission between …
Small Molecule Immunomodulators as Next-Generation Therapeutics for Glioblastoma
SA Abdel-Rahman, M Gabr - Cancers, 2024 - mdpi.com
Simple Summary Glioblastoma (GBM) is an aggressive brain tumor with limited treatment
success. Despite efforts, the prognosis remains poor, impacting patients' quality of life …
success. Despite efforts, the prognosis remains poor, impacting patients' quality of life …
CHI3L1 induces autophagy through the JNK pathway in lung cancer cells
CHI3L1 is closely related to the molecular mechanisms of cancer cell migration, growth, and
death. According to recent research, autophagy regulates tumor growth during various …
death. According to recent research, autophagy regulates tumor growth during various …