Dihydrofolate reductase inhibitors are an important class of drugs, as evidenced by their use
as antibacterial, antimalarial, antifungal, and anticancer agents. Progress in understanding …

The development of new mechanisms of resistance among pathogens, the occurrence and
transmission of genes responsible for antibiotic insensitivity, as well as cancer diseases …

Drug-resistant bacteria pose an increasingly serious threat to mankind all over the world.
However, the currently available clinical treatments do not meet the urgent demand …

Dihydrofolate reductase (DHFR), a core enzyme of folate metabolism, plays a crucial role in
the biosynthesis of purines and thymidylate for cell proliferation and growth in both …

Introduction Dihydrofolate reductase (DHFR) plays an important role in the biosynthesis of
amino acid and folic acid. It participates by reducing dihydrofolate to tetrahydrofolate, in the …

In the current research work, a new series of benzimidazole-1, 2, 3-triazole-indoline
derivatives (5a–r) were designed and synthesized by employing click reaction between …

Cinnamomum zeylanicum is a tropical plant with traditional medicinal significance that
possesses antimicrobial, antifungal, anti-parasitic, and anti-tumor properties. Here, we have …

A new strategy for designing and assembling a novel class of functionalized pyridine-based
benzothiazole and benzimidazole incorporating sulfonamide moieties was developed. The …

We report herein the utility of the morpholine-linked benzaldehyde as a key building block in
the preparation of two series of new chromene-thiazoles with potential bioactivities. In this …

The dihydrofolate reductase (DHFR) is a significant target in cancer, microbial infection,
fungal infection, malaria, leishmaniasis, and tuberculosis, among other diseases. The DHFR …