The single most common cause of the withdrawal or restriction of the use of marketed drugs
has been QT-interval prolongation associated with polymorphic ventricular tachycardia, or …

The prolonged QT interval is both widely seen and associated with the potentially deadly
rhythm, Torsades de Pointes (TdP). While it can occur spontaneously in the congenital form …

The drug-induced long QT syndrome is a distinct clinical entity that has evolved from an
electrophysiologic curiosity to a centerpiece in drug regulation and development. This …

Background—Drug-induced arrhythmia is one of the most common causes of drug
development failure and withdrawal from market. This study tested whether human induced …

Background—Identification of patients at risk for drug-induced torsades de pointes
arrhythmia (TdP) is difficult. Increased temporal lability of repolarization has been suggested …

The autonomic nervous system (ANS) with its two limbs, the sympathetic (SNS) and
parasympathetic nervous system (PSNS), plays a critical role in the modulation of cardiac …

Since its initial description by Jervell and Lange-Nielsen in 1957, the congenital long QT
syndrome (LQTS) has been the most investigated cardiac ion channelopathy. Although …

Background—The short-QT syndrome is a new clinical entity characterized by corrected QT
intervals< 300 ms and a high incidence of ventricular tachycardia (VT) and fibrillation (VF) …

Since its initial description by Jervell and Lange‐Nielsen in 1957, the congenital long QT
syndrome (LQTS) has been the most investigated cardiac ion channelopathy. Although …

Combined Congenital and Acquired LQTS. Introduction: A growing number of
cardiomyopathies have been shown to result in a reduction in both IKr and IKs, yet little is …