Three decades of genetic research in Alzheimer disease (AD) have substantially broadened
our understanding of the pathogenetic mechanisms leading to neurodegeneration and …

Advances in genetic and genomic technologies over the last thirty years have greatly
enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD) …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease
(AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 …

The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we …

The history of click-speaking Khoe-San, and African populations in general, remains poorly
understood. We genotyped∼ 2.3 million single-nucleotide polymorphisms in 220 southern …

The ɛ4 allele of the apolipoprotein E (APOE) gene is currently the strongest and most highly
replicated genetic factor for risk and age of onset of late-onset Alzheimer's disease (LOAD) …

Dementia is a complex human disease. The incidence of dementia among the elderly
population is rising rapidly worldwide. In the United States, Alzheimer's disease (AD) is the …

Alzheimer's disease (AD) represents the main form of dementia, and is a major public health
problem. Despite intensive research efforts, current treatments have only marginal …

In addition to apolipoprotein E (APOE), recent large genome-wide association studies
(GWASs) have identified nine other genes/loci (CR1, BIN1, CLU, PICALM, MS4A4/MS4A6E …

Alzheimer's disease (AD) is a complex disorder with a clear genetic component. Three
genes have been identified as the cause of early onset familial AD (EOAD). The most …