Introduction T HE hippocampus has received considerable attention as a potential regulator
of the hypothalamic-pituitary-adrenocortical (HPA) axis. After the demonstration by Harris' …

Why do we get the stress-related diseases we do? Why do some people have flare ups of
autoimmune disease, whereas others suffer from melancholic depression during a stressful …

Cognitive deficits following acute administration of corticosteroids have been described in
experimental animals and humans. In both populations, an inverted-U shape relationship …

For decades, demands associated with the predictable life-history cycle have been
considered stressful and have not been distinguished from stress that occurs in association …

Light is a powerful synchronizer of the circadian rhythms, and bright light therapy is known to
improve metabolic and hormonal status of circadian rhythm sleep disorders, although its …

The aim of the present study was to evaluate the pattern of basal cortisol release in PTSD
and major depression using a chronobiological analysis. Plasma for cortisol determination …

The brain occupies a special hierarchical position in the organism. It is separated from the
general circulation by the blood-brain barrier, has high energy consumption and a low …

Corticosteroids–secreted after stress–have profound effects on brain and behavior. These
effects are mediated by mineralocorticoid and glucocorticoid receptors, which are …

Corticosteroids play extremely important roles in fear and anxiety. The mechanisms by
which corticosteroids exert their effects on behavior are often indirect, because, although …

The development of the organism is subjected to critical and complex influences during the
perinatal period. Prenatal and postnatal stresses can have different long-term behavioral …