Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

The discovery of alternative signaling pathways that regulate cell death has revealed
multiple strategies for promoting cell death with diverse consequences at the tissue and …

Necroptosis is a physiological cell suicide mechanism initiated by receptor-interacting
protein kinase-3 (RIPK3) phosphorylation of mixed-lineage kinase domain-like protein …

Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered
when an organ undergoes a transient reduction or cessation of blood flow, followed by re …

Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …

Neuroinflammation and necroptosis are major contributors to neurodegenerative disease,
and axon dysfunction and degeneration is often an initiating event. SARM1 is the central …

Acute myocardial infarction causes lethal injury to cardiomyocytes during both ischaemia
and reperfusion (IR). It is important to define the precise mechanisms by which they die in …

The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However,
the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in …

Recently, necroptosis, as a programmed cell death pathway, has drawn much attention as it
has been implicated in multiple pathologies, especially in the field of inflammatory diseases …