Objectives The frontline drug doxorubicin has been used for treating cancer for over 30
years. While providing a cure in select cases, doxorubicin causes toxicity to most major …

The anthracycline doxorubicin (DOX) is widely used in chemotherapy due to its efficacy in
fighting a wide range of cancers such as carcinomas, sarcomas and hematological cancers …

Tubulointerstitial injury is an invariant finding in the chronically diseased kidney, irrespective
of the type of disease or the compartment in which the disease originates. Such histologic …

In patients with renal diseases characterized by proteinuria, the initial insult to the kidney is
usually followed by a progressive decline in the glomerular filtration rate. This decline has …

BACKGROUND: In diabetic nephropathy, angiotensin-converting-enzyme (ACE) inhibitors
have a greater effect than other antihypertensive drugs on proteinuria and the progressive …

The incidence of chronic kidney diseases is increasing worldwide, and these conditions are
emerging as a major public health problem. While genetic factors contribute to susceptibility …

The role of renin-angiotensin-aldosterone system in the progression of chronic kidney
disease The renin-angiotensin-aldosterone system (RAAS) is a well known regulator of …

Among the several theories on the pathophysiology of progressive nephropathies [1—41,
the most convincing one [1, 2] suggests that the initial reduction in nephron number …

The effect of thymoquinone (TQ), the main constituent of the volatile oil of Nigella sativa
seeds, on the nephropathy and oxidative stress induced by doxorubicin (DOX) in rats was …

Glomerular diseases remain the leading cause of chronic and end-stage kidney disease.
Significant advances in our understanding of human glomerular diseases have been …