Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …

Regeneration of damaged tissues or organs is one of the significant challenges in tissue
engineering and regenerative medicine. Many researchers have fabricated various scaffolds …

Abstract In his Lissner Award medal lecture in 2000, Stephen Cowin asked the
question:“How is a tissue built?” It is not a new question, but it remains as relevant today as it …

The clinical application of cytokine therapies for cancer treatment remains limited due to
severe adverse reactions and insufficient therapeutic effects. Although cytokine localization …

Extracellular vesicles (EVs) including plasma membrane–derived microvesicles and
endosomal-derived exosomes aggregate by unknown mechanisms, forming …

The extracellular microenvironment provides critical cues that guide tissue development,
homeostasis, and pathology. Deciphering the individual roles of these cues in tissue …

Angiogenesis is a key process that allows nutrient uptake and cellular trafficking and is
coopted in cancer to enable tumor growth and metastasis. Recently, extracellular vesicles …

In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an
affordable and practical approach for heart valve replacement; therefore, it is attractive for …

Ductal carcinoma in situ (DCIS) is a pre-invasive stage of breast cancer. During invasion, the
encapsulating DCIS basement membrane (BM) is compromised, and tumor cells invade the …

With its involvement in cell proliferation, migration and differentiation basic fibroblast growth
factor (bFGF) has great potential for tissue engineering purposes. So far, however, clinical …