Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT).
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …

Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.
Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute …

Metabolic reprogramming is widely observed during cancer development to confer cancer
cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting …

Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a
common feature of all cancers, requires fatty acids for synthesis of membranes and signaling …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Tumour growth and dissemination is largely dependent on nutrient availability. It has
recently emerged that the tumour microenvironment is rich in a diverse array of lipids that …

Citrate is an important substrate in cellular energy metabolism. It is produced in the
mitochondria and used in the Krebs cycle or released into cytoplasm through a specific …

Cancer cells are highly dependent on different metabolic pathways for sustaining their
survival, growth, and proliferation. Lipid metabolism not only provides the energetic needs of …