[HTML][HTML] Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms

M Jakaria, S Azam, ME Haque, SH Jo, MS Uddin… - Redox biology, 2019 - Elsevier
Taurine is a sulfur-containing amino acid and known as semi-essential in mammals and is
produced chiefly by the liver and kidney. It presents in different organs, including retina …

[HTML][HTML] Effects and mechanisms of taurine as a therapeutic agent

S Schaffer, HW Kim - Biomolecules & therapeutics, 2018 - ncbi.nlm.nih.gov
Taurine is an abundant, β-amino acid with diverse cytoprotective activity. In some species,
taurine is an essential nutrient but in man it is considered a semi-essential nutrient, although …

Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling

A Tauffenberger, H Fiumelli, S Almustafa… - Cell death & …, 2019 - nature.com
L-lactate was long considered a glycolytic by-product but is now being recognized as a
signaling molecule involved in cell survival. In this manuscript, we report the role of L-lactate …

Taurine protects dopaminergic neurons in a mouse Parkinson's disease model through inhibition of microglial M1 polarization

Y Che, L Hou, F Sun, C Zhang, X Liu, F Piao… - Cell death & …, 2018 - nature.com
Microglia-mediated neuroinflammation is implicated in multiple neurodegenerative
disorders, including Parkinson's disease (PD). Hence, the modulatioein of sustained …

Hepatorenal protective effects of taurine and N-acetylcysteine against fipronil-induced injuries: the antioxidant status and apoptotic markers expression in rats

MM Abdel-Daim, AA Dessouki… - Science of the total …, 2019 - Elsevier
Fipronil (FPN), a commonly used phenylpyrazole pesticide can induce oxidative tissue
damage following hazard usage. Due to the extensive household and commercial usage of …

Argon mediates protection by interleukin‐8 suppression via a TLR2/TLR4/STAT3/NF‐κB pathway in a model of apoptosis in neuroblastoma cells in vitro and following ischemia …

F Ulbrich, T Lerach, J Biermann… - Journal of …, 2016 - Wiley Online Library
Argon has recently come into scientific focus as a neuroprotective agent. The underlying
neuroprotective mechanism remains unknown although toll‐like receptors were recently …

Taurine protects dopaminergic neurons in paraquat-induced Parkinson's disease mouse model through PI3K/Akt signaling pathways

K Wang, B Zhang, T Tian, B Zhang, G Shi, C Zhang… - Amino Acids, 2022 - Springer
Taurine (Tau) is one of the most abundant amino acids in the brain and regulates
physiological functions in the central nervous system, including anti-inflammatory effects …

Evaluation of the adaptogenic potential exerted by ginsenosides Rb1 and Rg1 against oxidative stress-mediated neurotoxicity in an in vitro neuronal model

C Fernandez-Moriano, E Gonzalez-Burgos, I Iglesias… - PLoS …, 2017 - journals.plos.org
Background Ginseng (Panax sp.) is a drug with multiple pharmacological actions that has
been largely used in traditional medicines for the treatment of many health problems. In the …

N-acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease

E Polyak, J Ostrovsky, M Peng, SD Dingley… - Molecular Genetics and …, 2018 - Elsevier
Oxidative stress is a known contributing factor in mitochondrial respiratory chain (RC)
disease pathogenesis. Yet, no efficient means exists to objectively evaluate the comparative …

Antioxidant and cytoprotective effects of avocado oil and extract (Persea americana Mill) against rotenone using monkey kidney epithelial cells (Vero)

NF Queiroz Junior, JA Steffani, L Machado… - Journal of Toxicology …, 2021 - Taylor & Francis
Oxidative stress is known to be involved in development of numerous diseases including
cardiovascular, respiratory, renal, kidney and cancer. Thus, investigations that mimic …