Are cereal grasses a single genetic system?
In 1993, a passionate and provocative call to arms urged cereal researchers to consider the
taxon they study as a single genetic system and collaborate with each other. Since then, that …
taxon they study as a single genetic system and collaborate with each other. Since then, that …
Pharmacokinetics and pharmacogenomics of clozapine in an ancestrally diverse sample: a longitudinal analysis and genome-wide association study using UK clinical …
AF Pardiñas, DB Kappel, M Roberts, F Tipple… - The Lancet …, 2023 - thelancet.com
Background The antipsychotic, clozapine, is the only licensed drug against the treatment-
resistant symptoms that affect 20–30% of people with schizophrenia. Clozapine is markedly …
resistant symptoms that affect 20–30% of people with schizophrenia. Clozapine is markedly …
Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records
Obesity is a heritable disease, characterised by excess adiposity that is measured by body
mass index (BMI). While over 1,000 genetic loci are associated with BMI, less is known …
mass index (BMI). While over 1,000 genetic loci are associated with BMI, less is known …
Leveraging the genetic correlation between traits improves the detection of epistasis in genome-wide association studies
Epistasis, commonly defined as the interaction between genetic loci, is known to play an
important role in the phenotypic variation of complex traits. As a result, many statistical …
important role in the phenotypic variation of complex traits. As a result, many statistical …
Longitudinal characterization of impulsivity phenotypes boosts signal for genomic correlates and heritability
Genomic correlates of impulsivity have been identified in several genome-wide association
studies (GWAS) using cross-sectional designs, but no studies have investigated the …
studies (GWAS) using cross-sectional designs, but no studies have investigated the …
A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank
D He, H Liu, W Wei, Y Zhao, Q Cai, S Shi, X Chu… - Osteoporosis …, 2023 - Springer
Bone mineral density (BMD) is an essential predictor of osteoporosis and fracture. We
conducted a genome-wide trajectory analysis of BMD and analyzed the BMD change …
conducted a genome-wide trajectory analysis of BMD and analyzed the BMD change …
Genetic basis of pregnancy-associated decreased platelet counts and gestational thrombocytopenia
Platelet count reduction occurs throughout pregnancy, with 5% to 12% of pregnant women
being diagnosed with gestational thrombocytopenia (GT), characterized by a more marked …
being diagnosed with gestational thrombocytopenia (GT), characterized by a more marked …
The impact of major depressive disorder on glycaemic control in type 2 diabetes: a longitudinal cohort study using UK Biobank primary care records
AC Gillett, SP Hagenaars, D Handley, F Casanova… - BMC medicine, 2024 - Springer
Background This study evaluates longitudinal associations between glycaemic control,
measured by mean and within-patient variability of glycated haemaglobin (HbA1c) levels …
measured by mean and within-patient variability of glycated haemaglobin (HbA1c) levels …
JASPER: fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression
J Mbatchou, MS McPeek - The American Journal of Human Genetics, 2024 - cell.com
Joint association analysis of multiple traits with multiple genetic variants can provide insight
into genetic architecture and pleiotropy, improve trait prediction, and increase power for …
into genetic architecture and pleiotropy, improve trait prediction, and increase power for …
[HTML][HTML] The genetic architecture of changes in adiposity during adulthood
Obesity is a heritable disease, characterised by excess adiposity that is measured by body
mass index (BMI). While over 1,000 genetic loci are associated with BMI, less is known …
mass index (BMI). While over 1,000 genetic loci are associated with BMI, less is known …