Molecular photoswitches in aqueous environments

J Volarić, W Szymanski, NA Simeth… - Chemical Society …, 2021 - pubs.rsc.org
Molecular photoswitches enable dynamic control of processes with high spatiotemporal
precision, using light as external stimulus, and hence are ideal tools for different research …

Bioorthogonal chemistry and its applications

RE Bird, SA Lemmel, X Yu, QA Zhou - Bioconjugate Chemistry, 2021 - ACS Publications
Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional
groups to explore and understand biology in living organisms. In this review, we summarize …

Photoluminescent nanoparticles for chemical and biological analysis and imaging

WR Algar, M Massey, K Rees, R Higgins… - Chemical …, 2021 - ACS Publications
Research related to the development and application of luminescent nanoparticles (LNPs)
for chemical and biological analysis and imaging is flourishing. Novel materials and new …

Bioorthogonal chemistry

SL Scinto, DA Bilodeau, R Hincapie, W Lee… - Nature Reviews …, 2021 - nature.com
Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

Contemporary approaches to site-selective protein modification

EA Hoyt, PMSD Cal, BL Oliveira… - Nature Reviews …, 2019 - nature.com
Proteins constitute the majority of nature's worker biomolecules. Designed for specific
functions, complex tertiary structures make proteins ideal candidates for analysing natural …

Deciphering protein post-translational modifications using chemical biology tools

AC Conibear - Nature Reviews Chemistry, 2020 - nature.com
Proteins carry out a wide variety of catalytic, regulatory, signalling and structural functions in
living systems. Following their assembly on ribosomes and throughout their lifetimes, most …

NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications

C Jiang, H Huang, X Kang, L Yang, Z Xi… - Chemical Society …, 2021 - pubs.rsc.org
Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …

Cracking the code: reprogramming the genetic script in prokaryotes and eukaryotes to harness the power of noncanonical amino acids

C Jann, S Giofré, R Bhattacharjee, EA Lemke - Chemical Reviews, 2024 - ACS Publications
Over 500 natural and synthetic amino acids have been genetically encoded in the last two
decades. Incorporating these noncanonical amino acids into proteins enables many …

Chemical and enzymatic methods for post-translational protein–protein conjugation

RJ Taylor, MB Geeson, T Journeaux… - Journal of the …, 2022 - ACS Publications
Fusion proteins play an essential role in the biosciences but suffer from several key
limitations, including the requirement for N-to-C terminal ligation, incompatibility of …

[HTML][HTML] Recent developments in bioorthogonal chemistry and the orthogonality within

MLWJ Smeenk, J Agramunt, KM Bonger - Current Opinion in Chemical …, 2021 - Elsevier
The emergence of bioorthogonal reactions has greatly advanced research in the fields of
biology and medicine. They are not only valuable for labeling, tracking, and understanding …