Proteins are major targets for radicals and two-electron oxidants in biological systems due to
their abundance and high rate constants for reaction. With highly reactive radicals damage …

The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …

Throughout the last decade, interventions to engineer the immune system called
immunotherapy have revolutionized the fields of oncology and autoimmune disease …

Although it is well known that proteins are only marginally stable in their folded states, it is
often less well appreciated that most proteins are inherently aggregation-prone in their …

Novel tissue regeneration strategies are constantly being developed worldwide. Research
on bone regeneration is noteworthy, as many promising new approaches have been …

Nanogel has attracted considerable attention as one of the most versatile drug delivery
systems especially for site-specific and/or time-controlled delivery of bioactive agents owing …

Bone morphogenetic proteins (BMPs) are responsible for bone formation during
embryogenesis and bone regeneration and remodeling. The osteoinductive action of BMPs …

This review highlights how hydrogel formulations can improve intravitreal protein delivery to
the posterior segment of the eye in order to increase therapeutic outcome and patient …

Highlights•Proteins aggregate in a variety of ways, most of which are unwanted in drug
products.•Possible impacts on product quality include deliverability and immunogenicity.• …

The convenience of subcutaneous (SC) administration and the increasing interest in
monoclonal antibody (mAb)-based therapies for chronic diseases, hint their potential for SC …