Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

History and progress of hypotheses and clinical trials for Alzheimer's disease

PP Liu, Y Xie, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

Tau-targeting therapies for Alzheimer disease

EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated …

Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

CW Chang, E Shao, L Mucke - Science, 2021 - science.org
BACKGROUND The microtubule-associated protein tau has been implicated in the
pathogenesis of Alzheimer's disease and a range of other neurodegenerative disorders …

[HTML][HTML] Reconsideration of amyloid hypothesis and tau hypothesis in Alzheimer's disease

F Kametani, M Hasegawa - Frontiers in neuroscience, 2018 - frontiersin.org
The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …

[HTML][HTML] Complement C3 is activated in human AD brain and is required for neurodegeneration in mouse models of amyloidosis and tauopathy

T Wu, B Dejanovic, VD Gandham, A Gogineni… - Cell reports, 2019 - cell.com
Complement pathway overactivation can lead to neuronal damage in various neurological
diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau …

Roles of tau protein in health and disease

T Guo, W Noble, DP Hanger - Acta neuropathologica, 2017 - Springer
Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

The amyloid hypothesis of Alzheimer's disease at 25 years

DJ Selkoe, J Hardy - EMBO molecular medicine, 2016 - embopress.org
Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of
evidence from laboratories and clinics worldwide support the concept that an imbalance …

Mitochondria and calcium in Alzheimer's disease: from cell signaling to neuronal cell death

M Calvo-Rodriguez, BJ Bacskai - Trends in neurosciences, 2021 - cell.com
Mitochondrial dysfunction has been implicated in the pathogenesis of almost all
neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in …

Role of tau protein in Alzheimer's disease: The prime pathological player

S Muralidar, SV Ambi, S Sekaran, D Thirumalai… - International journal of …, 2020 - Elsevier
Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …