Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

This review is devoted to discussing recent progress on the structure, thermodynamic,
reactivity, and dynamics of water and aqueous systems confined within different types of …

Passive macromolecular diffusion through nuclear pore complexes (NPCs) is thought to
decrease dramatically beyond a 30–60-kD size threshold. Using thousands of independent …

In eukaryotes, the separation of translation from transcription by the nuclear envelope
enables mRNA modifications such as capping, splicing, and polyadenylation. These …

Nuclear pore complexes (NPCs) regulate all cargo traffic across the nuclear envelope. The
transport conduit of NPCs is highly enriched in disordered phenylalanine/glycine-rich …

Cellular proteins do not work in isolation. Instead, they often function as part of large
macromolecular complexes, which are transported and concentrated into specific cellular …

The hallmark of eukaryotic cells is the nucleus that contains the genome, enclosed by a
physical barrier known as the nuclear envelope (NE). On the one hand, this …

The permeability barrier of nuclear pore complexes (NPCs) controls nucleocytoplasmic
transport. It retains inert macromolecules but allows facilitated passage of nuclear transport …

Conspectus Multivalent interactions are common in biological systems and are also widely
deployed for targeting applications in biomedicine. A unique feature of multivalent binding is …

Nuclear pore complexes (NPCs) embedded within the nuclear envelope mediate rapid,
selective and bidirectional traffic between the cytoplasm and the nucleoplasm. Deciphering …