Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Exercise induces physiological cardiac growth and protects the heart against pathological
remodeling. Recent work suggests exercise also enhances the heart's capacity for repair …

Cushing's disease, also known as adrenocorticotropic hormone (ACTH)-secreting pituitary
adenomas (PAs) that cause excess cortisol production, accounts for up to 85% of …

Tumour cells undergo uncontrolled proliferation, yet tumours most often originate from adult
tissues, in which most cells are quiescent. So, the proliferative advantage of tumour cells …

The transactivation of TCF target genes induced by Wnt pathway mutations constitutes the
primary transforming event in colorectal cancer (CRC). We show that disruption of β …

A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the
activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such …

First identified as cell cycle inhibitors mediating the growth inhibitory cues of upstream
signaling pathways, the cyclin-CDK inhibitors of the Cip/Kip family p21Cip1, p27Kip1, and …

Transgenic mice expressing a stabilized β-catenin in neural precursors develop enlarged
brains with increased cerebral cortical surface area and folds resembling sulci and gyri of …

Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population
doublings before they cease proliferation and enter a growth-arrest state termed replicative …