Mechanisms and clinical implications of intervertebral disc calcification
Low back pain is a leading cause of disability worldwide. Intervertebral disc (IVD)
degeneration is often associated with low back pain but is sometimes asymptomatic. IVD …
degeneration is often associated with low back pain but is sometimes asymptomatic. IVD …
Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation
Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone
mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling …
mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling …
The mechanism of mineralization and the role of alkaline phosphatase in health and disease
H Orimo - Journal of Nippon Medical School, 2010 - jstage.jst.go.jp
Biomineralization is the process by which hydroxyapatite is deposited in the extracellular
matrix. Physiological mineralization occurs in hard tissues, whereas pathological …
matrix. Physiological mineralization occurs in hard tissues, whereas pathological …
Biomimetic systems for hydroxyapatite mineralization inspired by bone and enamel
The study of biomineralization is not only important to gain an understanding of how mineral-
rich tissues are created in vivo but also because it is a great source of inspiration for the …
rich tissues are created in vivo but also because it is a great source of inspiration for the …
Skeletal and extraskeletal disorders of biomineralization
MT Collins, G Marcucci, HJ Anders, G Beltrami… - Nature Reviews …, 2022 - nature.com
The physiological process of biomineralization is complex and deviation from it leads to a
variety of diseases. Progress in the past 10 years has enhanced understanding of the …
variety of diseases. Progress in the past 10 years has enhanced understanding of the …
[HTML][HTML] Well-oriented magnesium hydroxide nanoplatelets coating with high corrosion resistance and osteogenesis on magnesium alloy
Magnesium alloys are nontoxic and promising as orthopedic metallic implants, but preparing
a biocompatible Mg (OH) 2 layer with high corrosion protection ability remains challenging. It …
a biocompatible Mg (OH) 2 layer with high corrosion protection ability remains challenging. It …
MOFs and bone: application of MOFs in bone tissue engineering and bone diseases
X Li, X Shu, Y Shi, H Li, X Pei - Chinese Chemical Letters, 2023 - Elsevier
Abstract Metal-organic frameworks (MOFs), a class of hybrid materials, consist of organic
linkers and bridging metal ions or clusters. Their tunable pore sizes, large surface area …
linkers and bridging metal ions or clusters. Their tunable pore sizes, large surface area …
[PDF][PDF] Molecular and biophysical mechanisms regulating hypertrophic differentiation in chondrocytes and mesenchymal stem cells
Chondrocyte hypertrophy is one of the key physiological processes involved in the
longitudinal growth of long bones, yet regulation of hypertrophy is becoming increasingly …
longitudinal growth of long bones, yet regulation of hypertrophy is becoming increasingly …
[HTML][HTML] Strategies to minimize hypertrophy in cartilage engineering and regeneration
S Chen, P Fu, R Cong, HS Wu, M Pei - Genes & diseases, 2015 - Elsevier
Due to a blood supply shortage, articular cartilage has a limited capacity for self-healing
once damaged. Articular chondrocytes, cartilage progenitor cells, embryonic stem cells, and …
once damaged. Articular chondrocytes, cartilage progenitor cells, embryonic stem cells, and …
Calcium in health and disease
Evolution has exploited the chemical properties of Ca 2+, which facilitate its reversible
binding to the sites of irregular geometry offered by biological macromolecules, to select it as …
binding to the sites of irregular geometry offered by biological macromolecules, to select it as …