Nuclear magnetic resonance spectroscopy in clinical metabolomics and personalized medicine: current challenges and perspectives

MPM Letertre, P Giraudeau, P De Tullio - Frontiers in Molecular …, 2021 - frontiersin.org
Personalized medicine is probably the most promising area being developed in modern
medicine. This approach attempts to optimize the therapies and the patient care based on …

Biomarkers of hypoxic–ischemic encephalopathy: a systematic review

I Caramelo, M Coelho, M Rosado… - World Journal of …, 2023 - Springer
Background Current diagnostic criteria for hypoxic–ischemic encephalopathy in the early
hours lack objective measurement tools. Therefore, this systematic review aims to identify …

How could metabolomics change pediatric health?

F Bardanzellu, V Fanos - Italian Journal of Pediatrics, 2020 - Springer
In the last years,'omics' technologies, and especially metabolomics, emerged as expanding
scientific disciplines and promising technologies in the characterization of several …

Exploring perinatal asphyxia by metabolomics

E Locci, G Bazzano, R Demontis, A Chighine, V Fanos… - Metabolites, 2020 - mdpi.com
Brain damage related to perinatal asphyxia is the second cause of neuro-disability
worldwide. Its incidence was estimated in 2010 as 8.5 cases per 1000 live births worldwide …

Thiamine as a possible neuroprotective strategy in neonatal hypoxic-ischemic encephalopathy

GP Sechi, F Bardanzellu, MC Pintus, MM Sechi… - Antioxidants, 2021 - mdpi.com
On the basis that similar biochemical and histological sequences of events occur in the brain
during thiamine deficiency and hypoxia/ischemia related brain damage, we have planned …

Urinary metabotypes of newborns with perinatal asphyxia undergoing therapeutic hypothermia

E Valerio, V Mardegan, M Stocchero, ME Cavicchiolo… - Plos one, 2022 - journals.plos.org
Perinatal asphyxia (PA) still occurs in about three to five per 1,000 deliveries in developed
countries; 20% of these infants show hypoxic-ischemic encephalopathy (HIE) on brain …

Metabolomics investigation of post-mortem human pericardial fluid

A Chighine, M Stocchero, G Ferino… - International Journal of …, 2023 - Springer
Introduction Due to its peculiar anatomy and physiology, the pericardial fluid is a biological
matrix of particular interest in the forensic field. Despite this, the available literature has …

Metabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model

E Locci, A Chighine, A Noto, G Ferino, A Baldi… - Scientific reports, 2021 - nature.com
The diagnosis of mechanical asphyxia remains one of the most difficult issues in forensic
pathology. Asphyxia ultimately results in cardiac arrest (CA) and, as there are no specific …

A metabolomic approach in search of neurobiomarkers of perinatal asphyxia: a review of the current literature

MJ Debuf, K Carkeek, F Piersigilli - Frontiers in pediatrics, 2021 - frontiersin.org
Perinatal asphyxia and the possible sequelae of hypoxic-ischemic encephalopathy (HIE),
are associated with high morbidity and mortality rates. The use of therapeutic hypothermia …

The Urinary Metabolome of Newborns with Perinatal Complications

Y López-Hernández, V Lima-Rogel, R Mandal, J Zheng… - Metabolites, 2024 - mdpi.com
Maternal pathological conditions such as infections and chronic diseases, along with
unexpected events during labor, can lead to life-threatening perinatal outcomes. These …