From systemic lupus erythematosus to lupus nephritis: The evolving road to targeted therapies

M Xipell, GM Lledó, AC Egan, F Tamirou… - Autoimmunity …, 2023 - Elsevier
Systemic lupus erythematosus is a chronic autoimmune disease characterized by loss of
tolerance against nuclear and cytoplasmic self-antigens, induction of immunity and tissue …

Immunomodulatory effects of diet and nutrients in systemic lupus erythematosus (SLE): a systematic review

MA Islam, SS Khandker, PJ Kotyla… - Frontiers in …, 2020 - frontiersin.org
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple
organ involvement, including the skin, joints, kidneys, lungs, central nervous system and the …

Role of the innate and adaptive immune responses in the pathogenesis of systemic lupus erythematosus

N Bolouri, M Akhtari, E Farhadi, R Mansouri… - Inflammation …, 2022 - Springer
Objective Systemic lupus erythematosus (SLE), the most common form of lupus, is a
multisystemic rheumatic disease with different clinical features that generally affect women …

Baricitinib decreases anti-dsDNA in patients with systemic lupus erythematosus: results from a phase II double-blind, randomized, placebo-controlled trial

T Dörner, RF van Vollenhoven, A Doria, B Jia… - Arthritis research & …, 2022 - Springer
Background Patients with systemic lupus erythematosus (SLE) have substantial unmet
medical need. Baricitinib is a Janus kinase (JAK) 1 and 2 inhibitor that was shown to have …

Telitacicept, a novel humanized, recombinant TACI-Fc fusion protein, for the treatment of systemic lupus erythematosus.

Y Fan, D Gao, Z Zhang - Drugs of Today (Barcelona, Spain: 1998), 2022 - europepmc.org
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, in which aberrant
immune cells and proinflammatory mediators act as key players in the pathogenesis of the …

A novel serum tsRNA for diagnosis and prediction of nephritis in SLE

P Yang, X Zhang, S Chen, Y Tao, M Ning… - Frontiers in …, 2021 - frontiersin.org
Objective Dysregulation of transfer RNA (tRNA)-derived small noncoding RNA (tsRNA)
signatures in human serum has been found in various diseases. Here, we determine …

Systemic lupus erythematosus: Latest insight into etiopathogenesis

A Akhil, R Bansal, K Anupam, A Tandon… - Rheumatology …, 2023 - Springer
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder of unknown
etiology. Multifactorial interaction among various susceptible factors such as environmental …

Urinary exosome tsRNAs as novel markers for diagnosis and prediction of lupus nephritis

S Chen, X Zhang, K Meng, Y Sun, R Shu… - Frontiers in …, 2023 - frontiersin.org
Objective Lupus nephritis (LN) is one of the most severe organ manifestations of systemic
lupus erythematosus (SLE). Early identification of renal disease in SLE is important. Renal …

The role of neutrophil extracellular traps (NETs) in the pathogenesis of systemic lupus erythematosus and antiphospholipid syndrome

T Reshetnyak, K Nurbaeva - International Journal of Molecular Sciences, 2023 - mdpi.com
Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are two related
autoimmune diseases. In recent years, there has been sufficient evidence to suggest that …

Immunomodulatory effect of MSCs and MSCs-derived extracellular vesicles in systemic lupus erythematosus

C Yang, J Sun, Y Tian, H Li, L Zhang, J Yang… - Frontiers in …, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is a common autoimmune connective tissue disease
with unclear etiology and pathogenesis. Mesenchymal stem cell (MSC) and MSC derived …