Genetics and pathogenesis of dystonia

M Thomsen, LM Lange, M Zech… - Annual Review of …, 2024 - annualreviews.org
Dystonia is a clinically and genetically highly heterogeneous neurological disorder
characterized by abnormal movements and postures caused by involuntary sustained or …

Resting-state functional connectivity-based parcellation of the human dentate nucleus: new findings and clinical relevance

M Kulkarni, JS Kent, K Park, X Guell… - Brain Structure and …, 2023 - Springer
For years, the cerebellum was left out of functional magnetic resonance imaging (fMRI)
studies due to technological limitations. The advent of novel data acquisition and …

Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits

I Lazaridis, JR Crittenden, G Ahn, K Hirokane… - Current Biology, 2024 - cell.com
Balanced activity of canonical direct D1 and indirect D2 basal ganglia pathways is
considered a core requirement for normal movement, and their imbalance is an etiologic …

Cerebellar control of fear learning via the cerebellar nuclei–Multiple pathways, multiple mechanisms?

JD Urrutia Desmaison, RW Sala, A Ayyaz… - Frontiers in Systems …, 2023 - frontiersin.org
Fear learning is mediated by a large network of brain structures and the understanding of
their roles and interactions is constantly progressing. There is a multitude of anatomical and …

An integrated neurorobotics model of the cerebellar-basal ganglia circuitry

JM Pimentel, RC Moioli, MFP De Araujo… - International Journal of …, 2023 - World Scientific
This work presents a neurorobotics model of the brain that integrates the cerebellum and the
basal ganglia regions to coordinate movements in a humanoid robot. This cerebellar-basal …

White and gray matter alterations in de novo PD patients: which matter most?

S Pietracupa, D Belvisi, C Piervincenzi, S Tommasin… - Journal of …, 2023 - Springer
Objectives This paper aimed to identify white matter (WM) and gray matter (GM)
abnormalities in a sample of early PD patients, and their correlations with motor and non …

The role of the human cerebellum for learning from and processing of external feedback in non-motor learning: a systematic review

AM Berlijn, DM Huvermann, S Schneider, C Bellebaum… - The Cerebellum, 2024 - Springer
This review aimed to systematically identify and comprehensively review the role of the
cerebellum in performance monitoring, focusing on learning from and on processing of …

The effect of cerebellar TMS on error processing: A combined single-pulse TMS and ERP study

AM Berlijn, DM Huvermann, SJ Groiss… - Imaging …, 2024 - direct.mit.edu
The present study investigated temporal aspects of cerebellar contributions to the
processing of performance errors as indexed by the error-related negativity (ERN) in the …

Neuron specific quantitation of Gαolf expression and signaling in murine brain tissue

M Millett, A Heuberger, EM Castosa, A Comite… - Brain research, 2024 - Elsevier
The heterotrimeric G-protein α subunit, Gα olf, acts to transduce extracellular signals through
G-protein coupled receptors (GPCRs) and stimulates adenylyl cyclase mediated production …

Reinforcement motor learning after cerebellar damage is related to state estimation

CM White, EC Snow, AS Therrien - The Cerebellum, 2024 - Springer
Recent work showed that individuals with cerebellar degeneration could leverage intact
reinforcement learning (RL) to alter their movement. However, there was marked inter …