The α7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent
agonists, allosteric activating PAMs and neutral or silent allosteric modulators are …

Natural or synthetic chalcones with different substituents have revealed a variety of
biological activities that may benefit human health. The underlying mechanisms of action …

Background: Nicotine and nicotinic acetylcholine receptors (nAChRs) have been explored
for the past three decades as targets for pain control. The aim of this review is to introduce …

Streptococcus mutans has been implicated as the major etiological agent in the initiation
and the development of dental caries due to its robust capacity to form tenacious biofilms …

Infectious diseases, such as tuberculosis and invasive mycoses, represent serious health
problems. As a part of our long-term efforts to find new agents for the treatment of these …

In the adrenal gland, acetylcholine released on stimulation of the sympathetic splanchnic
nerve activates neuronal-type nicotinic receptors (nAChRs) in chromaffin cells and triggers …

The virtual screening of a library of chalcone derivatives led us to the identification of
potential new MDM2 ligands. The chalcones with the best docking scores obeying the …

The chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one), or 2HMC,
displays antileishmanial, antimalarial, and antioxidant activities. The aim of this study was to …

Objective: Alpinia elegans (Zingiberaceae) is a Philippine endemic plant reported to have
various folkloric uses. The seed oil of A. elegans has been shown to contain a majority of the …