Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

COVIDomics: The proteomic and metabolomic signatures of COVID-19

M Costanzo, M Caterino, R Fedele, A Cevenini… - International journal of …, 2022 - mdpi.com
Omics-based technologies have been largely adopted during this unprecedented global
COVID-19 pandemic, allowing the scientific community to perform research on a large scale …

Metabolomics in the Diagnosis and Prognosis of COVID-19

MR Hasan, M Suleiman, A Perez-Lopez - Frontiers in Genetics, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented global effort
in developing rapid and inexpensive diagnostic and prognostic tools. Since the genome of …

Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests

FA Castelli, G Rosati, C Moguet, C Fuentes… - Analytical and …, 2022 - Springer
Metabolomics refers to the large-scale detection, quantification, and analysis of small
molecules (metabolites) in biological media. Although metabolomics, alone or combined …

MetaboliteCOVID: A manually curated database of metabolite markers for COVID-19

L Ren, L Ning, Y Yang, T Yang, X Li, S Tan, P Ge… - Computers in Biology …, 2023 - Elsevier
In the realm of unraveling COVID-19's intricacies, numerous metabolomic investigations
have been conducted to discern the unique metabolic traits exhibited within infected …

Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome

I Roberts, M Wright Muelas, JM Taylor, AS Davison… - Metabolomics, 2022 - Springer
Introduction The diagnosis of COVID-19 is normally based on the qualitative detection of
viral nucleic acid sequences. Properties of the host response are not measured but are key …

Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patients

H Castañé, S Iftimie, G Baiges-Gaya… - Metabolism, 2022 - Elsevier
Background Lipids are involved in the interaction between viral infection and the host
metabolic and immunological responses. Several studies comparing the lipidome of COVID …

Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation

Y Li, JS Hook, Q Ding, X Xiao, SS Chung… - Nature …, 2023 - nature.com
Severe COVID-19 is characterized by an increase in the number and changes in the
function of innate immune cells including neutrophils. However, it is not known how the …

Defining blood plasma and serum metabolome by GC-MS

O Kiseleva, I Kurbatov, E Ilgisonis, E Poverennaya - Metabolites, 2021 - mdpi.com
Metabolomics uses advanced analytical chemistry methods to analyze metabolites in
biological samples. The most intensively studied samples are blood and its liquid …

Mass spectrometry-based metabolomics for clinical study: Recent progresses and applications

J Ding, YQ Feng - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
In clinical study, metabolomics aims to characterize the metabolic disturbance at the disease
state using large cohorts and further provides diagnostic evidence at the small molecular …