Update on hepatitis E virology: Implications for clinical practice

Y Debing, D Moradpour, J Neyts, J Gouttenoire - Journal of hepatology, 2016 - Elsevier
Hepatitis E virus (HEV) is a positive-strand RNA virus transmitted by the fecal-oral route. The
7.2 kb genome encodes three open reading frames (ORF) which are translated into (i) the …

Hepatitis E virus genome structure and replication strategy

SP Kenney, XJ Meng - Cold Spring …, 2019 - perspectivesinmedicine.cshlp.org
Hepatitis E virus (HEV) possesses many of the features of other positive-stranded RNA
viruses but also adds HEV-specific nuances, making its virus–host interactions unique. Slow …

Hepatitis E virus infection: circulation, molecular epidemiology, and impact on global health

SR Pallerla, D Harms, R Johne, D Todt, E Steinmann… - Pathogens, 2020 - mdpi.com
Infection with hepatitis E virus (HEV) represents the most common source of viral hepatitis
globally. Although infecting over 20 million people annually in endemic regions, with major …

A perspective on the prospective use of AI in protein structure prediction

R Versini, S Sritharan, B Aykac Fas… - Journal of Chemical …, 2023 - ACS Publications
AlphaFold2 (AF2) and RoseTTaFold (RF) have revolutionized structural biology, serving as
highly reliable and effective methods for predicting protein structures. This article explores …

Virus–host cell interplay during hepatitis E virus infection

MH Wißing, Y Brüggemann, E Steinmann, D Todt - Trends in microbiology, 2021 - cell.com
The molecular interplay between cellular host factors and viral proteins is a continuous
process throughout the viral life cycle determining virus host range and pathogenesis. The …

Hepatitis E virus inhibits type I interferon induction by ORF1 products

Y Nan, Y Yu, Z Ma, SK Khattar, B Fredericksen… - Journal of …, 2014 - Am Soc Microbiol
Hepatitis E virus (HEV) causes both endemic and epidemic human hepatitis by fecal-oral
transmission in many parts of the world. Zoonotic transmission of HEV from animals to …

Molecular biology and infection of hepatitis E virus

Y Nan, YJ Zhang - Frontiers in microbiology, 2016 - frontiersin.org
Hepatitis E virus (HEV) is a viral pathogen transmitted primarily via fecal-oral route. In
humans, HEV mainly causes acute hepatitis and is responsible for large outbreaks of …

Hepatitis E virus replication

R LeDesma, I Nimgaonkar, A Ploss - Viruses, 2019 - mdpi.com
Hepatitis E virus (HEV) is a small quasi-enveloped,(+)-sense, single-stranded RNA virus
belonging to the Hepeviridae family. There are at least 20 million HEV infections annually …

Zoonotic hepatitis E virus: an ignored risk for public health

Y Nan, C Wu, Q Zhao, EM Zhou - Frontiers in microbiology, 2017 - frontiersin.org
Hepatitis E virus (HEV) is a quasi-enveloped, single-stranded positive-sense RNA virus.
HEV belongs to the family Hepeviridae, a family comprised of highly diverse viruses …

De novo modelling of HEV replication polyprotein: Five-domain breakdown and involvement of flexibility in functional regulation

S Fieulaine, T Tubiana, S Bressanelli - Virology, 2023 - Elsevier
Hepatitis E virus (HEV), a major cause of acute viral hepatitis, is a single-stranded, positive-
sense RNA virus. As such, it encodes a 1700-residue replication polyprotein pORF1 that …