Abstract The Replication Protein A (RPA) complex is an essential regulator of eukaryotic
DNA metabolism. RPA avidly binds to single-stranded DNA (ssDNA) through multiple …

Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now
established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds …

Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during
cell cycle progression. Many important cell cycle regulators, including many oncogenes and …

Although protein ADP-ribosylation is involved in diverse biological processes, it has
remained a challenge to identify ADP-ribose acceptor sites. Here, we present an …

Maintenance of a genome requires DNA repair integrated with chromatin remodeling. We
have analyzed six transcriptome data sets and one data set on translational regulation of …

First discovered as a structure-specific endonuclease that evolved to cut at the base of
single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component …

Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …

The canonical Wnt signaling pathway (or Wnt/β-catenin pathway) plays a pivotal role in
embryonic development and adult homeostasis; deregulation of the Wnt pathway …

An increased DNA repair capacity is associated with drug resistance and limits the efficacy
of chemotherapy in breast cancers. Flap endonuclease 1 (FEN1) participates in various …