After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive.
There are many reasons why the development of a potent and durable HIV-1 vaccine is …

Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral
response to replicate and propagate to new hosts. The complex regulation of the IFN …

Acquired immunodeficiency syndrome (AIDS) of humans is caused by two lentiviruses,
human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the …

Chronic-phase HIV and simian immunodeficiency virus (SIV) replication is reduced by as
much as 10,000-fold in elite controllers (ECs) compared with typical progressors (TPs), but …

This review examines the enormous progress that has been made in the past decade in
understanding the origin of HIV, HIV genetic variability, and the impact of global HIV diversity …

Intrinsic antiviral immunity refers to a form of innate immunity that directly restricts viral
replication and assembly, thereby rendering a cell nonpermissive to a specific class or …

Retroviruses have long been a fertile model for discovering host–pathogen interactions and
their associated biological principles and processes. These advances have not only …

Mammalian genes and genomes have been shaped by ancient and ongoing challenges
from viruses. These genetic imprints can be identified via evolutionary analyses to reveal …

The ability of interferons (IFNs) to inhibit HIV-1 replication in cell culture models has long
been recognized, and the therapeutic administration of IFNα to HIV-1-infected patients who …

SAMHD1 restricts HIV-1 replication in myeloid and quiescent CD4+ T cells. Here, we show
that SAMHD1 restriction activity is regulated by phosphorylation. SAMHD1 interacts with …