Molecular origins of force-dependent protein complex stabilization during bacterial infections
The unbinding pathway of a protein complex can vary significantly depending on
biochemical and mechanical factors. Under mechanical stress, a complex may dissociate …
biochemical and mechanical factors. Under mechanical stress, a complex may dissociate …
Protein structure prediction in the era of AI: Challenges and limitations when applying to in silico force spectroscopy
Mechanoactive proteins are essential for a myriad of physiological and pathological
processes. Guided by the advances in single-molecule force spectroscopy (SMFS), we have …
processes. Guided by the advances in single-molecule force spectroscopy (SMFS), we have …
May the force be with you: The role of hyper-mechanostability of the bone sialoprotein binding protein during early stages of Staphylococci infections
PSFC Gomes, M Forrester, M Pace, DEB Gomes… - Frontiers in …, 2023 - frontiersin.org
The bone sialoprotein-binding protein (Bbp) is a mechanoactive MSCRAMM protein
expressed on the surface of Staphylococcus aureus that mediates adherence of the …
expressed on the surface of Staphylococcus aureus that mediates adherence of the …
GōMartini 3: From large conformational changes in proteins to environmental bias corrections
Coarse-grained modeling has become an important tool to supplement experimental
measurements, allowing access to spatio-temporal scales beyond all-atom based …
measurements, allowing access to spatio-temporal scales beyond all-atom based …
[PDF][PDF] A Biophysical and Biomechanical Study of the Central Rod Domain of Dystrophin
The purpose of this project was to predict accurate, high resolution tridimensional structures
for the spectrin-repeats (SR) of the central rod region of dystrophin. These structures can …
for the spectrin-repeats (SR) of the central rod region of dystrophin. These structures can …