A review of nanostructured delivery systems for the encapsulation, protection, and delivery of silymarin: An emerging nutraceutical

Z Zhang, X Li, S Sang, DJ McClements, L Chen… - Food Research …, 2022 - Elsevier
Silymarin exhibits biological activities that may promote human health and wellbeing,
including antioxidant, antimicrobial, anti-inflammatory, and anti-cancer activities …

Inhaled medicines for targeting non-small cell lung cancer

AO Al Khatib, M El-Tanani, H Al-Obaidi - Pharmaceutics, 2023 - mdpi.com
Throughout the years, considerable progress has been made in methods for delivering
drugs directly to the lungs, which offers enhanced precision in targeting specific lung …

Ion-triggered In Situ gelling nanoemulgel as a platform for nose-to-brain delivery of small lipophilic molecules

S Nagaraja, GM Basavarajappa, RK Karnati, EM Bakir… - Pharmaceutics, 2021 - mdpi.com
Background: Intranasal route offers a direct nose-to-brain delivery via olfactory and
trigeminal nerves and minimizes the systemic exposure of the drug. Although reliable and …

[HTML][HTML] Nanocarrier-based drug delivery to brain: interventions of surface modification

S Sharma, S Dang - Current neuropharmacology, 2023 - ncbi.nlm.nih.gov
Brain disorders are a prevalent and rapidly growing problem in the medical field as they
adversely affect the quality of life of a human. With an increase in life expectancy, it has been …

Non-cellular layers of the respiratory tract: protection against pathogens and target for drug delivery

E Fröhlich - Pharmaceutics, 2022 - mdpi.com
Epithelial barriers separate the human body from the environment to maintain homeostasis.
Compared to the skin and gastrointestinal tract, the respiratory barrier is the thinnest and …

Direct transport theory: From the nose to the brain

N Dhas, D Yadav, A Singh, A Garkal, R Kudarha… - Direct Nose-to-Brain …, 2021 - Elsevier
The delivery of drugs to CNS has been constrained due to the presence of blood-brain
barrier (BBB). The intranasal route involving several pathways (viz., olfactory, trigeminal, and …

Mucoadhesion as a strategy to enhance the direct nose-to-brain drug delivery

M Patil - Direct nose-to-brain drug delivery, 2021 - Elsevier
It is well apprehended that the nose-to-brain drug delivery system enables both small and
large molecules to bypass the BBB via the nerves of the nasal cavity, ie, the olfactory and …

Nanomaterials for therapeutic and theranostic applications: concepts, applications, and future perspectives

CV Pardeshi, EB Souto - … -based drug delivery systems: therapeutic and …, 2023 - Springer
Due to the encouraging outcomes, the use of nanomaterials has increased manifold for both
therapeutic and theranostic applications. Recently, different strategies have been employed …

New Insights into Nanoparticulate Carriers for Direct Nose‐to‐Brain Drug Delivery

CV Pardeshi, M Handa, R Shukla - Nanoengineering of …, 2022 - Wiley Online Library
Disorders related to central nervous system (CNS) like schizophrenia, Parkinson's disease,
and Alzheimer's disease need transport of the medication to the specific site in the brain for …

Strategies for Enhanced Drug Targeting to Inflamed Lungs: Novel Perspectives

CV Pardeshi, SR Pardeshi, JB Naik - Advanced Drug Delivery Strategies …, 2022 - Springer
Although most inflamed lung cases have been effectively managed, many cases are still
poorly controlled because of heterogeneity and variability in population due to the genetic …