The catastrophic failure of human metabolism observed in autoimmune disease results from
a common underlying pathogenesis–the successive accumulation of pathogens into the …

Studies of autoimmune disease have focused on the characteristics of the identifiable
antibodies. But as our knowledge of the genes associated with the disease states expands …

Background In the context of systems biology, few sparse approaches have been proposed
so far to integrate several data sets. It is however an important and fundamental issue that …

Adaptive laboratory evolution (ALE) has emerged as a valuable method by which to
investigate microbial adaptation to a desired environment. Here, we performed ALE to 42° C …

Background Short-term laboratory evolution of bacteria followed by genomic sequencing
provides insight into the mechanism of adaptive evolution, such as the number of mutations …

Bacterial leaf blight (BLB), caused by Xanthomonas oryzae pv. oryzae (Xoo), gives rise to
devastating crop losses in rice. Disease resistant rice cultivars are the most economical way …

Abstract Background Many Caenorhabditis elegans mutations increase longevity and much
evidence suggests that they do so at least partly via changes in metabolism. However, up …

Cell membranes exhibit multiple layers of complexity, ranging from their specific molecular
content to their emergent mechanical properties and dynamic spatial organization. Both …

Laboratory evolution is a powerful approach in applied and fundamental yeast research, but
complete elucidation of the molecular basis of evolved phenotypes remains a challenge. In …

Motivation: Although many tools are available to study variation and its impact in single
genomes, there is a lack of algorithms for finding such variation in metagenomes. This …