Dendrimer-based drug delivery systems: History, challenges, and latest developments
J Wang, B Li, L Qiu, X Qiao, H Yang - Journal of Biological Engineering, 2022 - Springer
Since the first dendrimer was reported in 1978 by Fritz Vögtle, dendrimer research has
grown exponentially, from synthesis to application in the past four decades. The distinct …
grown exponentially, from synthesis to application in the past four decades. The distinct …
Stimuli-responsive gene delivery nanocarriers for cancer therapy
Gene therapy provides a promising approach in treating cancers with high efficacy and
selectivity and few adverse effects. Currently, the development of functional vectors with …
selectivity and few adverse effects. Currently, the development of functional vectors with …
Smart transformable nanoparticles for enhanced tumor theranostics
The physical morphologies of nanoparticles, especially size and shape, always significantly
influence their biological behaviors. In the past, nanoparticles with constant physical …
influence their biological behaviors. In the past, nanoparticles with constant physical …
Rational design of cancer nanomedicine: nanoproperty integration and synchronization
Current cancer nanomedicines can only mitigate adverse effects but fail to enhance
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …
therapeutic efficacies of anticancer drugs. Rational design of next‐generation cancer …
Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration
Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …
pH-sensitive nano-systems for drug delivery in cancer therapy
Nanotechnology has been widely used in the development of new strategies for drug
delivery and cancer therapy. Compared to traditional drug delivery systems, nano-based …
delivery and cancer therapy. Compared to traditional drug delivery systems, nano-based …
Vaccine delivery systems toward lymph nodes
Y Ding, Z Li, A Jaklenec, Q Hu - Advanced drug delivery reviews, 2021 - Elsevier
Strategies of improving vaccine targeting ability toward lymph nodes have been attracting
considerable interest in recent years, though there are remaining delivery barriers based on …
considerable interest in recent years, though there are remaining delivery barriers based on …
pH-responsive polymer nanomaterials for tumor therapy
S Chu, X Shi, Y Tian, F Gao - Frontiers in oncology, 2022 - frontiersin.org
The complexity of the tumor microenvironment presents significant challenges to cancer
therapy, while providing opportunities for targeted drug delivery. Using characteristic signals …
therapy, while providing opportunities for targeted drug delivery. Using characteristic signals …
Tailor-made dual pH-sensitive polymer–doxorubicin nanoparticles for efficient anticancer drug delivery
Efficient delivery of therapeutics into tumor cells to increase the intracellular drug
concentration is a major challenge for cancer therapy due to drug resistance and inefficient …
concentration is a major challenge for cancer therapy due to drug resistance and inefficient …
Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy
To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier
into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance …
into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance …